1,5-anhydro-D-fructose reductase

1,5-anhydro-D-fructose reductase
Identifiers
EC no.	1.1.1.263
CAS no.	206138-19-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) is an enzyme that catalyzes the chemical reaction

1,5-Anhydroglucitol

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

1,5-Anhydro-D-fructose

+ NADPH

 

The two substrates of this enzyme are 1,5-anhydroglucitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 1,5-anhydro-D-fructose, reduced NADPH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP⁺ oxidoreductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GLX.

References

1. Enzyme 1.1.1.263 at KEGG Pathway Database.
2. Sakuma M, Kametani S, Akanuma H (January 1998). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose". Journal of Biochemistry. 123 (1): 189–93. doi: 10.1093/oxfordjournals.jbchem.a021909 . PMID   9504428.