2-Deoxy-scyllo-inosamine dehydrogenase

2-deoxy-scyllo-inosamine dehydrogenase
Identifiers
EC no.	1.1.1.329
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-deoxy-scyllo-inosamine dehydrogenase (EC 1.1.1.329, neoA (gene name), kanK (gene name)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:NAD(P)⁺ 1-oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

2-deoxy-scyllo-inosamine

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

3-amino-2,3-dideoxy-scyllo-inosose

+ NADH

 

The enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate and requires zinc. ^[3]

References

1. Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K (December 2005). "Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773". The Journal of Antibiotics. 58 (12): 766–74. doi: 10.1038/ja.2005.104 . PMID   16506694.
2. Nepal KK, Oh TJ, Sohng JK (May 2009). "Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853". Molecules and Cells. 27 (5): 601–8. doi: 10.1007/s10059-009-0080-5 . PMID   19466609.
3. Enzyme 1.1.1.329 at KEGG Pathway Database.

External links

• 2-deoxy-scyllo-inosamine+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)