2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

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2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
Identifiers
EC no. 1.1.1.127
CAS no. 37250-56-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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In enzymology, 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are (4S)-4,6-dihydroxy-2,5-dioxohexanoic acid, reduced NADH, and a proton. [1] [2] [3]

This enzyme participates in pentose and glucuronate interconversions.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase. Other names in common use include 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide, (phosphate)) dehydrogenase, 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic, and acid) dehydrogenase.

References

  1. Enzyme 1.1.1.127 at KEGG Pathway Database.
  2. Condemine G; Hugouvieux-Cotte-Pattat N; Robert-Baudouy J (1984). "An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase". J. Gen. Microbiol. 130 (11): 2839–2844. doi: 10.1099/00221287-130-11-2839 .
  3. Preiss J, Ashwell G (May 1963). "Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid". The Journal of Biological Chemistry. 238 (5): 1577–83. doi: 10.1016/S0021-9258(18)81103-6 . PMID   13986017.