2-dehydropantoate 2-reductase

2-dehydropantoate 2-reductase
Identifiers
EC no.	1.1.1.169
CAS no.	37211-74-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 2-dehydropantoate 2-reductase (EC 1.1.1.169) is an enzyme that catalyzes the chemical reaction

(R)-pantoic acid

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

ketopantoic acid

+ NADPH

 

The two substrates of this enzyme are (R)-pantoic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are ketopantoic acid, reduced NADPH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP⁺ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.

References

1. Enzyme 1.1.1.169 at KEGG Pathway Database.
2. King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. doi: 10.1016/S0021-9258(19)42375-2 . PMID   4603075.