2-deoxy-D-gluconate 3-dehydrogenase

2-deoxy-D-gluconate 3-dehydrogenase
Identifiers
EC no.	1.1.1.125
CAS no.	37250-54-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) is an enzyme that catalyzes the chemical reaction

2-deoxy-D-gluconic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

3-dehydro-2-deoxy-D-gluconic acid

+ NADH

 

The two substrates of this enzyme are 2-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 3-dehydro-2-deoxy-D-gluconic acid, reduced NADH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD⁺ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E.

References

1. Enzyme 1.1.1.125 at KEGG Pathway Database.
2. Eichhorn MM, Cynkin MA (January 1965). "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". Biochemistry. 4: 159–65. doi:10.1021/bi00877a024. PMID   14285233.