2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
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EC no. 1.1.1.312
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2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+

Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.

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<span class="mw-page-title-main">Aminomuconate-semialdehyde dehydrogenase</span>

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<span class="mw-page-title-main">Aspartate-semialdehyde dehydrogenase</span> Amino-acid-synthesizing enzyme in fungi, plants and prokaryota

In enzymology, an aspartate-semialdehyde dehydrogenase is an enzyme that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. This pathway also produces diaminopimelate which plays an essential role in bacterial cell wall formation. There is particular interest in ASADH as disabling this enzyme proves fatal to the organism giving rise to the possibility of a new class of antibiotics, fungicides, and herbicides aimed at inhibiting it.

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In enzymology, a saccharopine dehydrogenase (NADP+, L-glutamate-forming) (EC 1.5.1.10) is an enzyme that catalyzes the chemical reaction

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Succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79, succinic semialdehyde dehydrogenase (NADP+), succinyl semialdehyde dehydrogenase (NADP+), succinate semialdehyde:NADP+ oxidoreductase, NADP-dependent succinate-semialdehyde dehydrogenase, GabD) is an enzyme with systematic name succinate-semialdehyde:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85, xylG [gene], praB [gene] ) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

References

  1. ↑ Maruyama K, Ariga N, Tsuda M, Deguchi K (April 1978). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 83 (4): 1125–34. PMID   26671.
  2. ↑ Maruyama K (December 1979). "Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 86 (6): 1671–7. PMID   528534.
  3. ↑ Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry. 93 (2): 557–65. PMID   6841353.
  4. ↑ Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M (December 2000). "Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6". Journal of Bacteriology. 182 (23): 6651–8. doi:10.1128/jb.182.23.6651-6658.2000. PMC   111406 . PMID   11073908.
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