2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)

2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
Identifiers
EC no.	1.14.11.34
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) (EC 1.14.11.34, ethylene-forming enzyme, EFE) is an enzyme with systematic name L-arginine,2-oxoglutarate:oxygen oxidoreductase (succinate-forming). ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2-oxoglutarate + L-arginine + O₂${\displaystyle \rightleftharpoons }$ succinate + CO₂ + guanidine + (S)-1-pyrroline-5-carboxylate + H₂O (overall reaction)

(1a) 2-oxoglutarate + L-arginine + O₂${\displaystyle \rightleftharpoons }$ succinate + CO₂ + L-hydroxyarginine

(1b) L-hydroxyarginine ${\displaystyle \rightleftharpoons }$ guanidine + (S)-1-pyrroline-5-carboxylate + H₂O

2-oxoglutarate/L-arginine monooxygenase/decarboxylase catalyses two cycles of the ethylene-forming reaction.

References

1. Nagahama K, Ogawa T, Fujii T, Tazaki M, Tanase S, Morino Y, Fukuda H (October 1991). "Purification and properties of an ethylene-forming enzyme from Pseudomonas syringae pv. phaseolicola PK2". Journal of General Microbiology. 137 (10): 2281–6. doi: 10.1099/00221287-137-10-2281 . PMID   1770346.
2. Fukuda H, Ogawa T, Tazaki M, Nagahama K, Fujii T, Tanase S, Morino Y (October 1992). "Two reactions are simultaneously catalyzed by a single enzyme: the arginine-dependent simultaneous formation of two products, ethylene and succinate, from 2-oxoglutarate by an enzyme from Pseudomonas syringae". Biochemical and Biophysical Research Communications. 188 (2): 483–9. Bibcode:1992BBRC..188..483F. doi:10.1016/0006-291X(92)91081-Z. PMID   1445291.
3. Fukuda H, Ogawa T, Ishihara K, Fujii T, Nagahama K, Omata T, Inoue Y, Tanase S, Morino Y (October 1992). "Molecular cloning in Escherichia coli, expression, and nucleotide sequence of the gene for the ethylene-forming enzyme of Pseudomonas syringae pv. phaseolicola PK2". Biochemical and Biophysical Research Communications. 188 (2): 826–32. Bibcode:1992BBRC..188..826F. doi:10.1016/0006-291X(92)91131-9. PMID   1445325.

External links

• 2-oxoglutarate/L-arginine+monooxygenase/decarboxylase+(succinate-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)