25-hydroxycholesterol 7α-hydroxylase

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25-hydroxycholesterol 7alpha-hydroxylase
Identifiers
EC no. 1.14.13.100
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25-hydroxycholesterol 7alpha-hydroxylase (EC 1.14.13.100, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1 , CYP7B1 oxysterol 7alpha-hydroxylase) is an enzyme with systematic name cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

Contents

(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
(2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).

See also

Related Research Articles

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<span class="mw-page-title-main">Cholesterol 24-hydroxylase</span> Protein family

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In enzymology, a cholesterol 25-hydroxylase (EC 1.14.99.38) is an enzyme that catalyzes the chemical reaction

In enzymology, a cholesterol 7alpha-monooxygenase (EC 1.14.13.17) is an enzyme that catalyzes the chemical reaction

In enzymology, a lithocholate 6beta-hydroxylase (EC 1.14.13.94) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">CYP7B1</span> Protein-coding gene in the species Homo sapiens

25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

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Taurochenodeoxycholate 6alpha-hydroxylase (EC 1.14.13.97, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). This enzyme catalyses the following chemical reaction

Abieta-7,13-dien-18-ol hydroxylase (EC 1.14.13.109, CYP720B1, PTAO) is an enzyme with systematic name abieta-7,13-dien-18-ol,NADPH:oxygen oxidoreductase (18-hydroxylating). This enzyme catalyses the following chemical reaction

Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Cholesterol-5,6-oxide hydrolase (EC 3.3.2.11, cholesterol-epoxide hydrolase, ChEH) is an enzyme with systematic name 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase. This enzyme catalyses the following chemical reaction

24<i>S</i>-Hydroxycholesterol Chemical compound

24S-Hydroxycholesterol (24S-HC), also known as cholest-5-ene-3,24-diol or cerebrosterol, is an endogenous oxysterol produced by neurons in the brain to maintain cholesterol homeostasis. It was discovered in 1953 by Alberto Ercoli, S. Di Frisco, and Pietro de Ruggieri, who first isolated the molecule in the horse brain and then demonstrated its presence in the human brain.

References

  1. Toll A, Wikvall K, Sudjana-Sugiaman E, Kondo KH, Björkhem I (September 1994). "7 alpha hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7 alpha-hydroxylase". European Journal of Biochemistry. 224 (2): 309–16. doi:10.1111/j.1432-1033.1994.00309.x. PMID   7925343.
  2. Li-Hawkins J, Lund EG, Bronson AD, Russell DW (June 2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". The Journal of Biological Chemistry. 275 (22): 16543–9. doi: 10.1074/jbc.M001810200 . PMID   10748047.
  3. Ren S, Marques D, Redford K, Hylemon PB, Gil G, Vlahcevic ZR, Pandak WM (May 2003). "Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat". Metabolism. 52 (5): 636–42. doi:10.1053/meta.2003.50106. PMID   12759897.
  4. Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID   12543708.