3-(3-hydroxyphenyl)propanoate hydroxylase

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3-(3-hydroxyphenyl)propanoate hydroxylase
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EC no. 1.14.13.127
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3-(3-hydroxyphenyl)propanoate hydroxylase (EC 1.14.13.127, mhpA (gene)) is an enzyme with systematic name 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating). [1] [2] [3] [4] This enzyme catalyses the following chemical reaction

(1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
(2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+

3-(3-hydroxyphenyl)propanoate hydroxylase is a flavoprotein (FAD).

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Beta-carotene 3-hydroxylase (EC 1.14.13.129, beta-carotene 3,3'-monooxygenase, CrtZ) is an enzyme with systematic name beta-carotene,NADH:oxygen 3-oxidoreductase . This enzyme catalyses the following chemical reaction

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2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (EC 3.7.1.14, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase. This enzyme catalyses the following chemical reaction:

  1. (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + succinate
  2. (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + fumarate

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References

  1. ↑ Burlingame R, Chapman PJ (July 1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". Journal of Bacteriology. 155 (1): 113–21. PMC   217659 . PMID   6345502.
  2. ↑ Burlingame RP, Wyman L, Chapman PJ (October 1986). "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". Journal of Bacteriology. 168 (1): 55–64. PMC   213419 . PMID   3531186.
  3. ↑ Ferrández A, Garciá JL, Díaz E (April 1997). "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". Journal of Bacteriology. 179 (8): 2573–81. PMC   179006 . PMID   9098055.
  4. ↑ Díaz E, Ferrández A, García JL (June 1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". Journal of Bacteriology. 180 (11): 2915–23. PMC   107259 . PMID   9603882.
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