3-dehydro-L-gulonate 2-dehydrogenase

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3-dehydro-L-gulonate 2-dehydrogenase
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3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli
Identifiers
EC no. 1.1.1.130
CAS no. 37250-61-6
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MetaCyc metabolic pathway
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In enzymology, a 3-dehydro-L-gulonate 2-dehydrogenase (EC 1.1.1.130) is an enzyme that catalyzes the chemical reaction:

3-dehydro-L-gulonate + NAD(P)+ (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+

The 3 substrates of this enzyme are 3-dehydro-L-gulonate, NAD+, and NADP+, whereas its 4 products are (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

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References