3-hydroxypropionate dehydrogenase

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3-hydroxypropionate dehydrogenase
Identifiers
EC no. 1.1.1.59
CAS no. 9028-59-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
3-hydroxypropionate dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are 3-hydroxypropionic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 3-oxopropanoic acid, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD+ oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

References

  1. Enzyme 1.1.1.59 at KEGG Pathway Database.
  2. Den H, Robinson WG, Coon MJ (1959). "Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde". J. Biol. Chem. 234 (7): 1666–1671. doi: 10.1016/S0021-9258(18)69904-1 . PMID   13672942.