3alpha-hydroxysteroid dehydrogenase (B-specific)

Last updated
3-alpha-hydroxysteroid dehydrogenase (B-specific)
Identifiers
EC no. 1.1.1.50
CAS no. 9028-56-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical reaction

androsterone + NAD(P)+ 5alpha-androstane-3,17-dione + NAD(P)H + H+

The 3 substrates of this enzyme are androsterone, NAD+, and NADP+, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and sterognost 3alpha. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1AFS, 1FJH, 1FK8, 1LWI, 1RAL, 2DKN, and 2FVL.

Related Research Articles

In enzymology, an estradiol 17beta-dehydrogenase (EC 1.1.1.62) is an enzyme that catalyzes the chemical reaction

In enzymology, an indanol dehydrogenase (EC 1.1.1.112) is an enzyme that catalyzes the chemical reaction

Malate dehydrogenase (NADP<sup>+</sup>)

In enzymology, a malate dehydrogenase (NADP+) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction

In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (EC 1.1.1.170) is an enzyme that catalyzes the chemical reaction

In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction

In enzymology, a 21-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.150) is an enzyme that catalyzes the chemical reaction

In enzymology, a 21-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.151) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.239) is an enzyme that catalyzes the chemical reaction:

In enzymology, a 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase (EC 1.1.1.152) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">3alpha(or 20beta)-hydroxysteroid dehydrogenase</span> Class of enzymes

In enzymology, a 3alpha(or 20beta)-hydroxysteroid dehydrogenase (EC 1.1.1.53) is an enzyme that catalyzes the chemical reaction

In enzymology, a 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) is an enzyme that catalyzes the chemical reaction

In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction

In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">HSD17B6</span>

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.

3(or 17)alpha-hydroxysteroid dehydrogenase (EC 1.1.1.209, 3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase. This enzyme catalyses the chemical reaction

<span class="mw-page-title-main">5α-Pregnan-17α-ol-3,20-dione</span> Chemical compound

5α-Pregnan-17α-ol-3,20-dione, also known as 17α-hydroxy-dihydroprogesterone (17‐OH-DHP) is an endogenous steroid, a metabolite of 17α-hydroxyprogesterone.

References