4-hydroxybenzoyl-CoA reductase

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4-hydroxybenzoyl-CoA reductase
Identifiers
EC number 1.3.7.9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.7.9) is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction [1] [2]

Contents

benzoyl-CoA + acceptor + H2O 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme participates in benzoate degradation via coa ligation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:

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Benzoyl-CoA

Benzoyl-CoA is a molecule implied in the activity of the different enzymes 4-hydroxybenzoyl-CoA reductase, benzoyl-CoA reductase, benzoyl-CoA 3-monooxygenase, benzoate-CoA ligase, 2alpha-hydroxytaxane 2-O-benzoyltransferase, anthranilate N-benzoyltransferase, biphenyl synthase, glycine N-benzoyltransferase, ornithine N-benzoyltransferase and phenylglyoxylate dehydrogenase (acylating).

(R)-benzylsuccinyl-CoA dehydrogenase is an enzyme with systematic name (R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase. This enzyme catalyses the following chemical reaction

3-hydroxybenzoate—CoA ligase is an enzyme with systematic name 3-hydroxybenzoate:CoA ligase (AMP-forming). This enzyme catalyses the following chemical reaction

Thauera aromatica is a species of bacteria. Its type strain is K 172T.

Azoarcus evansii is a species of bacteria. Its type strain is KB 740T.

Phenylacetyl-CoA

Phenylacetyl-CoA (C29H42N7O17P3S) is a form of acetyl-CoA formed from the condensation of the thiol group from Coenzyme A with the carboxyl group of phenylacetic acid.

References

  1. Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS Lett. 251 (1–2): 237–40. doi: 10.1016/0014-5793(89)81461-9 . PMID   2753161. S2CID   34285295.
  2. Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G (August 1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. doi:10.1007/s002030050623. PMID   9683649. S2CID   34536644.

Further reading