5-amino-6-(5-phosphoribosylamino)uracil reductase

5-amino-6-(5-phosphoribosylamino)uracil reductase
Identifiers
EC no.	1.1.1.193
CAS no.	69020-28-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) is an enzyme that catalyzes the chemical reaction

5-amino-6-(5-phospho-D-ribitylamino)uracil

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

5-amino-6-(5-phospho-β-D-ribosylamino)uracil

+ NADPH

 

The two substrates of this enzyme are 5-amino-6-(5-phospho-D-ribitylamino)uracil and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 5-amino-6-(5-phospho-β-D-ribosylamino)uracil, reduced NADPH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP⁺ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 2AZN, 2B3Z, 2D5N, 2G6V, 2HXV, 2O7P, and 2OBC.

References

1. Enzyme 1.1.1.193 at KEGG Pathway Database.
2. Burrows RB, Brown GM (1978). "Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin". J. Bacteriol. 136 (2): 657–67. doi:10.1128/JB.136.2.657-667.1978. PMC   218591 . PMID   30756.