6-hydroxyhexanoate dehydrogenase

6-hydroxyhexanoate dehydrogenase
Identifiers
EC no.	1.1.1.258
CAS no.	77000-03-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

6-oxohexanoic acid

+ NADH

 

The two substrates of this enzyme are 6-hydroxyhexanoic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 6-oxohexanoic acid, reduced NADH, and a proton. ^{[1] [2] [3]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD⁺ oxidoreductase. This enzyme participates in caprolactam degradation.

References

1. Enzyme 1.1.1.258 at KEGG Pathway Database.
2. Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi: 10.1111/j.1432-1033.1975.tb20968.x . PMID   1261.
3. Hecker LI, Tondeur Y, Farrelly JG (1984). "Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate". Chem. Biol. Interact. 49 (1–2): 235–48. Bibcode:1984CBI....49..235H. doi:10.1016/0009-2797(84)90064-4. PMID   6722936.