Acetoacetyl-CoA synthase

Last updated
Acetoacetyl-CoA synthase
Identifiers
EC no. 2.3.1.194
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Acetoacetyl-CoA synthase (EC 2.3.1.194, NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating). [1] This enzyme catalyses the following chemical reaction

acetyl-CoA + malonyl-CoA acetoacetyl-CoA + CoA + CO2

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA.

References

  1. Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T (June 2010). "Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway". Proceedings of the National Academy of Sciences of the United States of America. 107 (25): 11265–70. Bibcode:2010PNAS..10711265O. doi: 10.1073/pnas.1000532107 . PMC   2895072 . PMID   20534558.