Apolipoprotein A-II

Last updated

APOA2
Protein APOA2 PDB 1l6l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases APOA2 , Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDs OMIM: 107670; MGI: 88050; HomoloGene: 1242; GeneCards: APOA2; OMA:APOA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001643

NM_013474
NM_001305549
NM_001305550
NM_001305585

RefSeq (protein)

NP_001634

NP_001292478
NP_001292479
NP_001292514
NP_038502

Location (UCSC) Chr 1: 161.22 – 161.22 Mb Chr 1: 171.05 – 171.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
ApoA-II
PDB 1l6l EBI.jpg
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
SymbolApoA-II
Pfam PF04711
InterPro IPR006801
SCOP2 1l6k / SCOPe / SUPFAM
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. [5] It is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear. [6] Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [7]

Contents

Interactions

ApoA-II has been shown to interact with phospholipid transfer protein. [8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

[[File:
StatinPathway WP430.png go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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StatinPathway WP430.png go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Statin pathway edit]]
Statin pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158874 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005681 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. doi: 10.1016/S0021-9258(18)95725-X . PMID   2415515.
  6. Tailleux A, Duriez P, Fruchart JC, Clavey V (September 2002). "Apolipoprotein A-II, HDL metabolism and atherosclerosis". Atherosclerosis. 164 (1): 1–13. doi:10.1016/s0021-9150(01)00751-1. ISSN   0021-9150. PMID   12119188.
  7. "Entrez Gene: APOA2 apolipoprotein A-II".
  8. Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. doi: 10.1016/S0022-2275(20)34211-5 . PMID   9469594.

Further reading