Arterial stiffness

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Arterial stiffness
Biological system arteries

Arterial stiffness occurs as a consequence of biological aging and arteriosclerosis. [1] Inflammation plays a major role in arteriosclerosis development, and consequently it is a major contributor in large arteries stiffening. [2] Increased arterial stiffness is associated with an increased risk of cardiovascular events such as myocardial infarction, hypertension, heart failure and stroke, the two leading causes of death in the developed world. [3] [4] [5] The World Health Organization predicts that in 2010, cardiovascular disease will also be the leading killer in the developing world and represents a major global health problem.[ citation needed ]

Contents

Several degenerative changes that occur with age in the walls of large elastic arteries are thought to contribute to increased stiffening over time, including the mechanical fraying of lamellar elastin structures within the wall due to repeated cycles of mechanical stress; changes in the kind and increases in content of arterial collagen proteins, partially as a compensatory mechanism against the loss of arterial elastin and partially due to fibrosis; and crosslinking of adjacent collagen fibers by advanced glycation endproducts (AGEs). [6]

Background

When the heart contracts it generates a pulse or energy wave that travels through the circulatory system. The speed of travel of this pulse wave (pulse wave velocity [7] (PWV)) is related to the stiffness of the arteries. Other terms that are used to describe the mechanical properties of arteries include elastance, or the reciprocal (inverse) of elastance, compliance. The relationship between arterial stiffness and pulse wave velocity was first predicted by Thomas Young in his Croonian Lecture of 1808 [8] but is generally described by the Moens–Korteweg equation [9] or the Bramwell–Hill equation. [10] Typical values of PWV in the aorta range from approximately 5 m/s to >15 m/s.[ citation needed ]

Measurement of aortic PWV provides some of the strongest evidence concerning the prognostic significance of large artery stiffening. Increased aortic PWV has been shown to predict cardiovascular, and in some cases all cause, mortality in individuals with end stage kidney disease, [11] hypertension, [12] diabetes mellitus [13] and in the general population. [14] [15] However, at present, the role of measurement of PWV as a general clinical tool remains to be established. Devices are on the market that measure arterial stiffness parameters (augmentation index, pulse wave velocity). These include Complior, CVProfilor, PeriScope, Hanbyul Meditech, Mobil-O-Graph NG, BP Plus (Pulsecor), PulsePen, BPLab Vasotens, Arteriograph, Vascular Explorer, and SphygmoCor. [16]

Pathophysiological consequences of increased arterial stiffness

The primary sites of end-target organ damage following an increase in arterial stiffness are the heart, the brain (stroke, white matter hyperintensities (WMHs)), and the kidneys (age-related loss of kidney function). The mechanisms linking arterial stiffness to end-organ damage are several-fold.[ citation needed ]

Firstly, stiffened arteries compromise the Windkessel effect of the arteries. [17] The Windkessel effect buffers the pulsatile ejection of blood from the heart converting it into a more steady, even outflow. This function depends on the elasticity of the arteries and stiffened arteries require a greater amount of force to permit them to accommodate the volume of blood ejected from the heart (stroke volume). This increased force requirement equates to an increase in pulse pressure. [17] The increase in pulse pressure may result in increased damage to blood vessels in target organs such as the brain or kidneys. [18] [19] This effect may be exaggerated if the increase in arterial stiffness results in reduced wave reflection and more propagation of the pulsatile pressure into the microcirculation. [18]

An increase in arterial stiffness also increases the load on the heart, since it has to perform more work to maintain the stroke volume. Over time, this increased workload causes left ventricular hypertrophy and left ventricular remodelling, which can lead to heart failure. [20] The increased workload may also be associated with a higher heart rate, a proportionately longer duration of systole and a comparative reduction of duration of diastole. [21] This decreases the amount of time available for perfusion of cardiac tissue, which largely occurs in diastole. [17] Thus the hypertrophic heart, which has a greater oxygen demand, may have a compromised supply of oxygen and nutrients.[ citation needed ]

Arterial stiffness may also affect the time at which pulse wave reflections return to the heart. As the pulse wave travels through the circulation it undergoes reflection at sites where the transmission properties of the arterial tree change (i.e. sites of impedance mismatch). These reflected waves propagate backwards towards the heart. The speed of propagation (i.e. PWV [7] ) is increased in stiffer arteries and consequently reflected waves will arrive at the heart earlier in systole. This increases the load on the heart in systole. [22] Elevated PWV could represent an important parameter for identifying children with CKD and high cardiovascular risk. [23]

See also

Notes

  1. ↑ Winder, Nick R.; Reeve, Emily H.; Walker, Ashley E. (2021-01-01). "Large artery stiffness and brain health: insights from animal models". American Journal of Physiology-Heart and Circulatory Physiology. 320 (1): H424–H431. doi:10.1152/ajpheart.00696.2020. ISSN   0363-6135. PMC   7847068 . PMID   33164578.
  2. ↑ Mozos I, Malainer C, Horbańczuk J, Gug C, Stoian D, Luca CT, Atanasov AG. Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. Front Immunol. 2017 Aug 31;8:1058. doi: 10.3389/fimmu.2017.01058.
  3. ↑ Demir S, Akpınar O, Akkus O, Nas K, Unal I, Molnar F, et al. The prognostic value of arterial stiffness in systolic heart failure. Cardiol J 2013; 20:665–671.
  4. ↑ Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37:1236–1241.
  5. ↑ Edgell H., Stickland M.K., Maclean J.E. A simplified measurement of pulse wave velocity is not inferior to standard measurement in young adults and children. Blood Press. Monit.. 2016;21(3):192-195. doi:10.1097/MBP.0000000000000183
  6. ↑ Dietz, J (2007). "Arterial stiffness and extracellular matrix". Atherosclerosis, Large Arteries and Cardiovascular Risk. Adv. Cardiol. Advances in Cardiology. Vol. 44. pp. 76–95. doi:10.1159/000096722. ISBN   978-3-8055-8176-9. PMID   17075200.
  7. 1 2 Nabeel, P. M.; Kiran, V. Raj; Joseph, Jayaraj; Abhidev, V. V.; Sivaprakasam, Mohanasankar (2020). "Local Pulse Wave Velocity: Theory, Methods, Advancements, and Clinical Applications". IEEE Reviews in Biomedical Engineering. 13: 74–112. doi:10.1109/RBME.2019.2931587. ISSN   1937-3333. PMID   31369386. S2CID   199381680.
  8. ↑ Young (1809). "On the function of the heart and arteries: The Croonian lecture". Philos Trans R Soc. 99: 1–31. doi:10.1098/rstl.1809.0001. JSTOR   109672. S2CID   110648919.
  9. ↑ Nichols WW, O'Rourke MF. Vascular impedance. In: McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 4th ed. London, UK: Edward Arnold; 1998:54–97, 243–283, 347–395.
  10. ↑ Bramwell JC, Hill AV (1922). "The velocity of the pulse wave in man". Proceedings of the Royal Society of London B. 93 (652): 298–306. Bibcode:1922RSPSB..93..298C. doi: 10.1098/rspb.1922.0022 . JSTOR   81045.
  11. ↑ Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM (May 1999). "Impact of aortic stiffness on survival in end-stage renal disease". Circulation. 99 (18): 2434–9. doi: 10.1161/01.cir.99.18.2434 . PMID   10318666.
  12. ↑ Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A (May 2001). "Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients". Hypertension. 37 (5): 1236–41. CiteSeerX   10.1.1.583.3137 . doi:10.1161/01.hyp.37.5.1236. PMID   11358934. S2CID   8417352.
  13. ↑ Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG (October 2002). "Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?". Circulation. 106 (16): 2085–90. doi: 10.1161/01.cir.0000033824.02722.f7 . PMID   12379578.
  14. ↑ Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC (February 2006). "Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study". Circulation. 113 (5): 657–63. doi: 10.1161/CIRCULATIONAHA.105.555235 . PMID   16461838.
  15. ↑ Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, Jeppesen J (February 2006). "Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population". Circulation. 113 (5): 664–70. doi: 10.1161/CIRCULATIONAHA.105.579342 . PMID   16461839.
  16. ↑ Avolio A, Butlin M, Walsh A (2009). "Arterial blood pressure measurement and pulse wave analysis - their role in enhancing cardiovascular assessment". Physiological Measurement. 31 (1): R1–R47. doi:10.1088/0967-3334/31/1/r01. PMID   19940350. S2CID   20651222. Also noted are newer pulse wave velocity measurement tools like the iHeart Internal Age device, a fingertip device that measures aortic pulse wave velocity and arterial stiffness through the pulse in the finger.
  17. 1 2 3 Nicolaas Westerhof; Nikolaos Stergiopulos; Mark I.M. Noble (2 September 2010). Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education. Springer Science & Business Media. pp. 181–. ISBN   978-1-4419-6363-5.
  18. 1 2 Mitchell, Gary F. (2015). "Arterial stiffness". Current Opinion in Nephrology and Hypertension. 24 (1): 1–7. doi:10.1097/MNH.0000000000000092. ISSN   1062-4821. PMID   25470012. S2CID   23321317.
  19. ↑ Fernandez-Fresnedo, G.; Rodrigo, E.; de Francisco, A. L. M.; de Castro, S. S.; Castaneda, O.; Arias, M. (2006). "Role of Pulse Pressure on Cardiovascular Risk in Chronic Kidney Disease Patients". Journal of the American Society of Nephrology. 17 (12_suppl_3): S246–S249. doi: 10.1681/ASN.2006080921 . ISSN   1046-6673. PMID   17130269.
  20. ↑ Cheng, S.; Vasan, R. S. (2011). "Advances in the Epidemiology of Heart Failure and Left Ventricular Remodeling". Circulation. 124 (20): e516–e519. doi:10.1161/CIRCULATIONAHA.111.070235. ISSN   0009-7322. PMC   3621875 . PMID   22083151.
  21. ↑ Whelton, S. P.; Blankstein, R.; Al-Mallah, M. H.; Lima, J. A. C.; Bluemke, D. A.; Hundley, W. G.; Polak, J. F.; Blumenthal, R. S.; Nasir, K.; Blaha, M. J. (2013). "Association of Resting Heart Rate With Carotid and Aortic Arterial Stiffness: Multi-Ethnic Study of Atherosclerosis". Hypertension. 62 (3): 477–484. doi:10.1161/HYPERTENSIONAHA.113.01605. ISSN   0194-911X. PMC   3838105 . PMID   23836802.
  22. ↑ Pavelescu, Carmen (2021). "www.mdpi.com". Diagnostics (Basel, Switzerland). 12 (1). doi: 10.3390/diagnostics12010071 . PMC   8774385 . PMID   35054238.
  23. ↑ Wilmer W. Nichols; Michael F. O'Rourke (25 February 2005). McDonald's Blood Flow in Arteries 5Ed: Theoretical, experimental and clinical principles. Taylor & Francis. ISBN   978-0-340-80941-9.

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