Aryl-alcohol oxidase

Last updated
aryl-alcohol oxidase
Identifiers
EC no. 1.1.3.7
CAS no. 9028-77-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, an aryl-alcohol oxidase (EC 1.1.3.7) is an enzyme that catalyzes the chemical reaction

an aromatic primary alcohol + O2 an aromatic aldehyde + H2O2

An example is the oxidation of benzyl alcohol to benzaldehyde. [1] [2]

 
O2
H2O2
Aryl-alcohol oxidase
O2
H2O2
 

The two substrates of this enzyme are an aromatic primary alcohol and oxygen. Its products are the corresponding aromatic aldehyde and hydrogen peroxide.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is aryl-alcohol:oxygen oxidoreductase. Other names in common use include aryl alcohol oxidase, veratryl alcohol oxidase, and arom. alcohol oxidase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1E8F, 1E8H, 1QLT, and 1QLU.

References

  1. Enzyme 1.1.3.7 at KEGG Pathway Database.
  2. FARMER VC, HENDERSON ME, RUSSELL JD (1960). "Aromatic-alcohol-oxidase activity in the growth medium of Polystictus versicolor". Biochem. J. 74 (2): 257–62. doi:10.1042/bj0740257. PMC   1204151 . PMID   13821599.