Bartholin gland carcinoma

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Bartholin gland carcinoma
Other namesBartholin's gland cancer, Bartholin's gland carcinoma (morphologic abnormality), carcinoma of Bartholin's gland (disorder) [1]
American journal of obstetrics and gynecology (1920) (14745090456).jpg
Barthlin carcinoma tissue cross section
Specialty Oncology, gynecology
Symptoms Painless soft swelling at one side of the vaginal opening [2]
Usual onsetTypically in the 50s [3]
CausesUnknown [2]
FrequencyRare, <1% of all female genital tract cancer, <5% of vulvar cancer [2]

Bartholin gland carcinoma is a type of cancer of the vulva arising in the Bartholin gland. [2] It typically presents with a painless mass at one side of the vaginal opening in a female of middle-age and older, and can appear similar to a Bartholin cyst. [2] The mass may be big or small, may be deep under skin or appear nearer the surface with overlying ulceration. [2] Average age at presentation is 53-years. [3]

Contents

The tumor can become large before a woman is aware of symptoms. One of the first symptoms can be painful sex. In other instances, there may be a mass or ulcer in the vulva area. Many clinicians assume that an enlarged Bartholin gland is malignant in a postmenopausal woman until proven otherwise. The growth of the tumor can spread to nearby areas such as the ischiorectal fossa and inguinal lymph nodes. Approximately 50% of bartholin gland carcinomas originate from squamous cell carcinomas. Another uncommon characteristic of Bartholin gland malignancies is that the growth of a lesion originates from the three types of epithelial tissue present in the gland: mucinous, transitional, and squamous. [4]

It is rare, accounting for less than 1% of all female genital tract cancer and less than 5% of all vulva cancer. [2]

Cause

The cause is unknown. [2]

Diagnosis

Bartholin gland can be differentiated by histology to determine whether the malignancy is due to squamous cell carcinoma, adenoid cystic carcinoma, or adenocarcinomas. [5]

Management

Though Bartholin gland carcinoma is rare, along with other unusual Bartholin gland growths, it many not be the typical practice for clinicians to consider lesions malignant. Early diagnosis can help to prevent the cancer from spreading from the glands to the surrounding. Though malignancies of the Bartholin gland are rare, clinicians biopsy Bartholin gland lesions in older women or when the growth reoccurs or does not respond to original treatment. [4]

Prognosis

The prognosis is optimistic as long as the growth has not metastasized to the lymph nodes. [4]

History

Bartholin glands were described in cattle by Casper Bartholin in 1677. Their existence in humans was postulated at that time. [4] Treatment can be a vulvectomy that results in the removal of the growth along with an extensive removal of adjacent tissue. An inguinal lymphadenectomy often accompanies the vulvectomy. The tissue that is removed sometimes includes sections of the vagina and rectum. [6]

Illustration of Bartholin glands vaginal abscesses. Diseases of women. A clinical guide to their diagnosis and treatment (1899) (14767986892).jpg
Illustration of Bartholin glands vaginal abscesses.

The adenoid cystic carcinoma of the Bartholin gland is another uncommon malignancy with symptoms that include local painful intermittent recurrences. The disease is slow to progress, but it can result in lung cancer after a long time after the initial treatment. Treatment consists of surgical removal of the growth. Sometimes, radiation and chemotherapy are performed. [7]

References

  1. ↑ "Bartholin's gland carcinoma". Wikidata. Retrieved 2016-06-14.
  2. 1 2 3 4 5 6 7 8 WHO Classification of Tumours Editorial Board, ed. (2020). "10. Tumours of the vulva: Bartholin gland carcinoma". Female genital tumours: WHO Classification of Tumours. Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. p. 442. ISBN   978-92-832-4504-9.
  3. 1 2 Broach, Vance; Lawson, Barrett (2022). "Chapter 18 - Bartholin gland carcinomas". In Frumovitz, Michael; Leitao, Mario M. Jr.; Preetha, Ramalingam (eds.). Diagnosis and Treatment of Rare Gynecologic Cancers. Amsterdam: Elsevier. pp. 305–314. ISBN   978-0-323-82938-0.
  4. 1 2 3 4 Heller, Debra S.; Bean, Sarah (2014). "Lesions of the Bartholin Gland". Journal of Lower Genital Tract Disease. 18 (4): 351–357. doi:10.1097/LGT.0000000000000016. ISSN   1089-2591. PMID   24914884.
  5. ↑ Di Donato, Violante; Casorelli, Assunta; Bardhi, Erlisa; Vena, Flaminia; Marchetti, Claudia; Muzii, Ludovico; Panici, Pierluigi Benedetti (2017). "Bartholin gland cancer". Critical Reviews in Oncology/Hematology. 117: 1–11. doi:10.1016/j.critrevonc.2017.06.005. PMID   28807231.
  6. ↑ Clinical gynecologic oncology, Philip DiSaia, editor. Chapter 8, Invasive Cancer of the Vulva, Jeanne M. Schilder, and Frederick B. Stehman. Pages 219-244. Elsevier/Saunders.(2012). ISBN   978-0-323-07419-3; Access provided by the University of Pittsburgh.
  7. ↑ Clinical gynecologic oncology, Phillip Saia, editor. Chapter 8, Invasive Cancer of the Vulva, Jeanne M. Schilder, and Frederick B. Stehman. Pages 219-244. Elsevier/Saunders.(2012). ISBN   978-0-323-07419-3; Access provided by the University of Pittsburgh.
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