Mucinous cystadenoma

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Mucinous cystadenoma
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Micrograph showing a mucinous cystadenoma of the ovary. H&E stain.
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Mucinous cystadenoma is a benign cystic tumor lined by a mucinous epithelium. It is a type of cystic adenoma (cystadenoma).

Contents

Mucinous cystadenomas arise in a number of locations; however, cases of mucinous cystadenoma at different locations are not generally considered to be related to one another.

Overview

Mucinous cystadenomas may be found in the:

Ovarian mucinous cystadenoma

Mucinous cystadenomas make up 15–20% of all ovarian tumors. They often become very large and can extend up into the abdomen.

These tumors are usually evaluated using ultrasound, CT scan, or MRI. Findings on imaging studies are nonspecific. These ovarian tumors are usually multi-septated, cystic masses with thin walls. They also contain varying amounts of solid tissue which consists of proliferating stromal tissue, papillae, or malignant tumor cells.

Benign mucinous cystadenomas compose 80% of mucinous ovarian tumors [2] and 20–25% of benign ovarian tumors overall. The peak incidence occurs between 30 and 50 years of age. Benign tumors are bilateral in 5–10% of cases.

Macroscopy

Microscopy

Types

Pancreatic

Pancreatic mucinous cystadenoma or mucinous cystadenoma of the pancreas (MCN) are a type of mucinous cystic neoplasm of the pancreas. [3] The cure rate is very high in cases on benign cystic lesions, but the case changes if malignant changes ensue. [4] Benign cystadenomas are the most common cystic tumors of the pancreas accounting for 75% of the cases. On average, mucinous accounts for 40–50% of cystic tumors, and serous cytadenoma accounts for 30% of it. Mucinous cystadenomas are in the distal pancreas in about 80% of the cases and distal pancreatectomy is needed for resection. [4] In 20% of the cases it is in the head of the pancreas. [3]

Earlier it was believed that MCN occurs exclusively in women who are middle aged. However, occasional occurrence in men have been reported, [3] especially those who are 45 years of age or above. [5]

Liver

A rare neoplasm, 95% of cases occur in women, especially at the mean age of 45. [6] Biliary cystadenoma and cystadenocarcinoma constitute less than 5% of intrahepatic cysts originating from the bile duct. [6]

Cystadenomas in liver are often confused with hydatid cyst as their appearance on various imaging techniques is nearly same. [7] Treating cystadenomas as hydatid cyst has resulted in recurrence of the cyst. [7]

Primary retroperitoneal

Cases of primary retroperitoneal mucinous cystadenoma (PRMC) are extremely rare. However, they are observed more frequently in women, with only four cases having been found in men. [8] Even though mucinous cystadenoma are common ovarian tumor, what makes PRMC so rare is their retroperitoneal location.

PRMC and benign mucinous cystadenoma of the ovary are microscopically similar. Both are multiloculated cystic neoplasms and are lined by a single layer of tall columnar cells with a clear basal nucleus and cytoplasm. Both of them have identical histochemical and ultrastructural features. [9] Flat to low cuboidal cells, resembling mesothelial cells, in the lining interspersed between columnar cells in the same area is the only histological difference between the two tumors. [9]

See also

Related Research Articles

<span class="mw-page-title-main">Cyst</span> Closed sac growth on the body

A cyst, also traditionally known from Old English as a wen, is a closed sac, having a distinct envelope and division compared with the nearby tissue. Hence, it is a cluster of cells that have grouped together to form a sac ; however, the distinguishing aspect of a cyst is that the cells forming the "shell" of such a sac are distinctly abnormal when compared with all surrounding cells for that given location. A cyst may contain air, fluids, or semi-solid material. A collection of pus is called an abscess, not a cyst. Once formed, a cyst may resolve on its own. When a cyst fails to resolve, it may need to be removed surgically, but that would depend upon its type and location.

<span class="mw-page-title-main">Krukenberg tumor</span> Medical condition

A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Krukenberg tumors are often found in both ovaries, consistent with its metastatic nature.

<span class="mw-page-title-main">Ovarian mucinous tumor</span> Type of tumor

Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% of all ovarian tumors. Approximately 75% are benign, 10% are borderline and 15% are malignant. Rarely, the tumor is seen bilaterally; approximately 5% of primary mucinous tumors are bilateral.

<span class="mw-page-title-main">Serous tumour</span> Medical condition

A serous tumour is a neoplasm that typically has papillary to solid formations of tumor cells with crowded nuclei, and which typically arises on the modified Müllerian-derived serous membranes that surround the ovaries in females. Such ovarian tumors are part of the surface epithelial-stromal tumour group of ovarian tumors. They are common neoplasms with a strong tendency to occur bilaterally, and they account for approximately a quarter of all ovarian tumors.

<span class="mw-page-title-main">Surface epithelial-stromal tumor</span> Medical condition

Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium or from ectopic endometrial or fallopian tube (tubal) tissue. Tumors of this type are also called ovarian adenocarcinoma. This group of tumors accounts for 90% to 95% of all cases of ovarian cancer; however is mainly only found in postmenopausal women with the exception of the United States where 7% of cases occur in women under the age of 40. Serum CA-125 is often elevated but is only 50% accurate so it is not a useful tumor marker to assess the progress of treatment. 75% of women with epithelial ovarian cancer are found within the advanced-stages; however younger patients are more likely to have better prognoses than older patients.

<span class="mw-page-title-main">Pseudomyxoma peritonei</span> Medical condition

Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells that produce abundant mucin or gelatinous ascites. The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity. This will result in compression of organs and will destroy the function of the colon, small intestine, stomach, or other organs. Prognosis with treatment in many cases is optimistic, but the disease is lethal if untreated, with death occurring via cachexia, bowel obstruction, or other types of complications.

<span class="mw-page-title-main">Pancreatectomy</span> Surgical removal of the pancreas

In medicine, a pancreatectomy is the surgical removal of all or part of the pancreas. Several types of pancreatectomy exist, including pancreaticoduodenectomy, distal pancreatectomy, segmental pancreatectomy, and total pancreatectomy. In recent years, the TP-IAT has also gained respectable traction within the medical community. These procedures are used in the management of several conditions involving the pancreas, such as benign pancreatic tumors, pancreatic cancer, and pancreatitis.

<span class="mw-page-title-main">Cystadenoma</span> Medical condition

Cystadenoma is a type of cystic adenoma. When malignant, it is called cystadenocarcinoma.

Pancreatic diseases are diseases that affect the pancreas, an organ in most vertebrates and in humans and other mammals located in the abdomen. The pancreas plays a role in the digestive and endocrine system, producing enzymes which aid the digestion process and the hormone insulin, which regulates blood sugar levels. The most common pancreatic disease is pancreatitis, an inflammation of the pancreas which could come in acute or chronic form. Other pancreatic diseases include diabetes mellitus, exocrine pancreatic insufficiency, cystic fibrosis, pseudocysts, cysts, congenital malformations, tumors including pancreatic cancer, and hemosuccus pancreaticus.

<span class="mw-page-title-main">Cystadenocarcinoma</span> Medical condition

Cystadenocarcinoma is a malignant form of a cystadenoma and is a cancer derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. Similar tumor histology has also been reported in the pancreas, although it is a considerably rarer entity representing 1–1.5% of all Pancreatic cancer.

<span class="mw-page-title-main">Intraductal papillary mucinous neoplasm</span> Medical condition

Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. IPMN tumors produce mucus, and this mucus can form pancreatic cysts. Although intraductal papillary mucinous neoplasms are benign tumors, they can progress to pancreatic cancer. As such IPMN is viewed as a precancerous condition. Once an intraductal papillary mucinous neoplasm has been found, the management options include close monitoring and pre-emptive surgery.

Mucinous cystadenocarcinoma of the lung (MCACL) is a very rare malignant mucus-producing neoplasm arising from the uncontrolled growth of transformed epithelial cells originating in lung tissue.

<span class="mw-page-title-main">Pancreatic serous cystadenoma</span> Medical condition

Pancreatic serous cystadenoma is a benign tumour of the pancreas. It is usually solitary and found in the body or tail of the pancreas, and may be associated with von Hippel–Lindau syndrome.

<span class="mw-page-title-main">Ovarian serous cystadenoma</span> Medical condition

Ovarian serous cystadenoma, also known as serous cystadenoma, is the most common ovarian neoplasm, representing 20% of ovarian neoplasms, and is benign.

<span class="mw-page-title-main">Solid pseudopapillary tumour</span> Medical condition

A solid pseudopapillary tumour is a low-grade malignant neoplasm of the pancreas of papillary architecture that typically afflicts young women.

Ovarian cystadenoma is a cystic benign tumor of the ovary. Two types are recognized: serous and mucinous.Ovarian cystadenomas are common benign epithelial neoplasms that carry an excellent prognosis.

<span class="mw-page-title-main">Cystic lesions of the pancreas</span> Medical condition

Cystic lesions of the pancreas are a group of pancreatic lesions characterized by a cystic appearance. They can be benign or malignant.

<span class="mw-page-title-main">Pancreatic cyst</span> Medical condition

A pancreatic cyst is a fluid filled sac within the pancreas.

A mucinous cystic neoplasm is an abnormal and excessive growth of tissue (neoplasm) that typically has elements of mucin and one or more cysts. By location, they include:

Pancreatic mucinous cystic neoplasm (MCN) is a type of cystic lesion that occurs in the pancreas. Amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were mucinous cystic neoplasms. These lesions are benign, though there is a high rate of progression to cancer. As such, surgery should be pursued when feasible. The rate of malignancy present in MCN is about 10 percent. If resection is performed before invasive malignancy develops, prognosis is excellent. The extent of invasion is the single most important prognostic factor in predicting survival.

References

  1. Grubor NM, Colovic RB, Atkinson HD, Micev MT (2013). "Giant biliary mucinous cystadenoma of the liver". Annals of Hepatology. 12 (6): 979–983. doi: 10.1016/S1665-2681(19)31306-7 . PMID   24114831.
  2. Hart WR (January 2005). "Mucinous tumors of the ovary: a review". International Journal of Gynecological Pathology. 24 (1): 4–25. PMID   15626914.
  3. 1 2 3 Weerakkody Y. "Mucinous cystadenoma of the pancreas". Radiology Reference Article. Radiopaedia.org. Retrieved 2019-09-21.
  4. 1 2 Weledji EP, Eyongetah D, Nana TC, Ngowe MN (February 2018). "Excision of mucinous cystadenoma of pancreas is safe and effective: a case report". IJS Oncology. 3 (2): e47. doi:10.1097/IJ9.0000000000000047. ISSN   2471-3864. S2CID   80040000.
  5. Kuo E, Gonzalez RS (15 April 2021). Hagen CE (ed.). "Mucinous cystic neoplasm (MCN)". www.pathologyoutlines.com. Retrieved 2019-09-21.
  6. 1 2 Jain D (9 January 2013). "Biliary cystadenoma". www.pathologyoutlines.com. Archived from the original on 13 February 2014. Retrieved 2019-09-21.
  7. 1 2 Ahmad Z, Uddin N, Memon W, Abdul-Ghafar J, Ahmed A (November 2017). "Intrahepatic biliary cystadenoma mimicking hydatid cyst of liver: a clinicopathologic study of six cases". Journal of Medical Case Reports. 11 (1): 317. doi: 10.1186/s13256-017-1481-2 . PMC   5680786 . PMID   29121977.
  8. Lee SY, Han WC (February 2016). "Primary Retroperitoneal Mucinous Cystadenoma". Annals of Coloproctology. 32 (1): 33–37. doi:10.3393/ac.2016.32.1.33. PMC   4783510 . PMID   26962534.
  9. 1 2 Subramony C, Habibpour S, Hashimoto LA (May 2001). "Retroperitoneal mucinous cystadenoma". Archives of Pathology & Laboratory Medicine. 125 (5): 691–694. doi:10.5858/2001-125-0691-RMC. PMID   11300948.