CAPN5

CAPN5
Identifiers
Aliases	CAPN5 , ADNIV, HTRA3, VRNI, nCL-3, calpain 5
External IDs	OMIM: 602537; MGI: 1100859; HomoloGene: 31212; GeneCards: CAPN5; OMA:CAPN5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.5 Start 77,066,961 bp [1] End 77,126,155 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E1 Start 98,121,559 bp [2] End 98,178,274 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum gallbladder right lobe of liver stromal cell of endometrium mucosa of esophagus duodenum body of stomach mucosa of ileum palpebral conjunctiva Top expressed in transitional epithelium of urinary bladder lumbar spinal ganglion pyloric antrum epithelium of stomach conjunctival fornix mucous cell of stomach perirhinal cortex fetal liver hematopoietic progenitor cell corneal stroma entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity hydrolase activity calcium-dependent cysteine-type endopeptidase activity Cellular component cell surface extracellular exosome intracellular anatomical structure focal adhesion cytoplasm Biological process signal transduction proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 726 12337 Ensembl ENSG00000149260 ENSMUSG00000035547 UniProt O15484 O08688 RefSeq (mRNA) NM_004055 NM_001301250 NM_007602 RefSeq (protein) NP_004046 NP_001288179 NP_031628 Location (UCSC) Chr 11: 77.07 – 77.13 Mb Chr 7: 98.12 – 98.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene. ^{[5] [6] [7]}

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000149260 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035547 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID   9503024.
6. Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID   9367857.
7. "Entrez Gene: CAPN5 calpain 5".

Further reading

• Vanderklish PW, Bahr BA (2001). "The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states". International Journal of Experimental Pathology. 81 (5): 323–39. doi:10.1111/j.1365-2613.2000.00169.x. PMC   2517738 . PMID   11168679.
• Sato K, Kawashima S (2002). "Calpain function in the modulation of signal transduction molecules". Biol. Chem. 382 (5): 743–51. doi:10.1515/BC.2001.090. PMID   11517927. S2CID   882390.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Dear N, Matena K, Vingron M, Boehm T (1997). "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution". Genomics. 45 (1): 175–84. doi:10.1006/geno.1997.4870. PMID   9339374.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Waghray A, Wang DS, McKinsey D, et al. (2004). "Molecular cloning and characterization of rat and human calpain-5". Biochem. Biophys. Res. Commun. 324 (1): 46–51. doi:10.1016/j.bbrc.2004.09.012. PMID   15464980.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• González A, Sáez ME, Aragón MJ, et al. (2006). "Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome". Hum. Reprod. 21 (4): 943–51. doi: 10.1093/humrep/dei443 . PMID   16396936.
• Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R, et al. (2007). "Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels". BMC Med. Genet. 8: 1. doi: 10.1186/1471-2350-8-1 . PMC   1783645 . PMID   17227582.

External links

• The MEROPS online database for peptidases and their inhibitors: C02.011 Archived 2005-03-08 at the Wayback Machine
• Human CAPN5 genome location and CAPN5 gene details page in the UCSC Genome Browser .
• Human HTRA3 genome location and HTRA3 gene details page in the UCSC Genome Browser .