CASP14 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CASP14 , caspase 14, ARCI12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605848 MGI: 1335092 HomoloGene: 36304 GeneCards: CASP14 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. [5] [6] [7]
The CASP14 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [7]
According to the Human Protein Atlas, [8] the CASP14 protein is enriched human skin and mainly expressed in the upper layers of the epidermis. The protein is mainly localised to the cytosol according to the Cell Atlas. [9]
Keratin 1 is a member of the keratin family. It is specifically expressed in the spinous and granular layers of the epidermis with family member keratin 10. Mutations in this gene have been associated with the variants of bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected.
Keratin 15 is a protein that in humans is encoded by the KRT15 gene.
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers. In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. This protein is also a determinant for the GIL blood group system.
Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. CASP2 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.
Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene.
S100 calcium-binding protein A7 (S100A7), also known as psoriasin, is a protein that in humans is encoded by the S100A7 gene.
P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.
Peroxisome proliferator-activated receptor beta or delta, also known as NR1C2 is a nuclear receptor that in humans is encoded by the PPARD gene.
P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.
Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) also known as CD66c, is a member of the carcinoembryonic antigen (CEA) gene family..
Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.
Desmocollin-3 is a protein that in humans is encoded by the DSC3 gene.
Cystatin-M is a protein that in humans is encoded by the CST6 gene.
Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.
Serpin B13 is a protein that in humans is encoded by the SERPINB13 gene.
Periphilin-1 is a protein that in humans is encoded by the PPHLN1 gene.
Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene. Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin.
Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.