Calpain-9

CAPN9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZIV, 2P0R
Identifiers
Aliases	CAPN9 , GC36, nCL-4, calpain 9
External IDs	OMIM: 606401; MGI: 1920897; HomoloGene: 38208; GeneCards: CAPN9; OMA:CAPN9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.2 Start 230,747,384 bp [1] End 230,802,003 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E2 Start 125,302,850 bp [2] End 125,345,470 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment rectum mucosa of transverse colon body of stomach gastric mucosa mucosa of ileum olfactory zone of nasal mucosa bronchial epithelial cell pancreatic ductal cell right lung Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach lumbar spinal ganglion embryo duodenum left colon jejunum intestinal villus morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding peptidase activity cysteine-type peptidase activity hydrolase activity metal ion binding calcium-dependent cysteine-type endopeptidase activity Cellular component intracellular anatomical structure cytoplasm cellular component Biological process digestion proteolysis sarcomere organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10753 73647 Ensembl ENSG00000135773 ENSMUSG00000031981 UniProt O14815 Q9D805 RefSeq (mRNA) NM_006615 NM_016452 NM_001319676 NM_023709 RefSeq (protein) NP_001306605 NP_006606 NP_057536 NP_076198 Location (UCSC) Chr 1: 230.75 – 230.8 Mb Chr 8: 125.3 – 125.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene. ^{[5] [6] [7]}

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000135773 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031981 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem. 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID   9524069. S2CID   37483841.
6. Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC   5926377 . PMID   10835488.
7. "Entrez Gene: CAPN9 calpain 9".

Further reading

• Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355–362. doi:10.1016/S1471-4914(01)02049-4. PMID   11516996.
• Suzuki K, Sorimachi H, Yoshizawa T, et al. (1996). "Calpain: novel family members, activation, and physiologic function". Biol. Chem. Hoppe-Seyler. 376 (9): 523–9. doi:10.1515/bchm3.1995.376.9.523. PMID   8561910.
• Davis TL, Walker JR, Finerty PJ, et al. (2007). "The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition". J. Mol. Biol. 366 (1): 216–229. doi:10.1016/j.jmb.2006.11.037. PMID   17157313.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lee HJ, Tomioka S, Kinbara K, et al. (1999). "Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system". Arch. Biochem. Biophys. 362 (1): 22–31. doi:10.1006/abbi.1998.1021. PMID   9917325.

External links

• Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser .
• The MEROPS online database for peptidases and their inhibitors: C02.006
• Overview of all the structural information available in the PDB for UniProt : O14815 (Human Calpain-9 (CAPN9)) at the PDBe-KB .