CAPN1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CAPN1 , CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 114220 MGI: 88263 HomoloGene: 3800 GeneCards: CAPN1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Calpain-1 catalytic subunit(CANP 1) is a protein that in humans is encoded by the CAPN1 gene. [5] [6] [7]
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. [7]
A calpain is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.
Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.
Calpain-3 is a protein that in humans is encoded by the CAPN3 gene.
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.
Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.
Presenilin-2 is a protein that is encoded by the PSEN2 gene.
Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.
Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.
Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.
Calpain small subunit 1(CSS1), is a protein that in humans is encoded by the CAPNS1 gene.
Beta-adducin is a protein that in humans is encoded by the ADD2 gene.
Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.
Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.
Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.
Peflin is a protein that in humans is encoded by the PEF1 gene.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.
Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene.
Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.