Caspase 5

Search for
Structures	Swiss-model
Domains	InterPro

caspase 5, apoptosis-related cysteine peptidase
caspase 5, apoptosis-related cysteine peptidase
Identifiers
Symbol	CASP5
Alt. symbols	ICE(rel)III, ICH3
NCBI gene	838
HGNC	1506
OMIM	602665
RefSeq	NM_004347
UniProt	P51878
Other data
EC number	3.4.22.58
Locus	Chr. 11 q22.2-q22.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Last updated May 01, 2025

Intrinsic and Extrinsic pathways of caspase activation Apop1.png — Intrinsic and Extrinsic pathways of caspase activation

Caspase 5 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. It is an inflammatory caspase, along with caspase 1, caspase 4 and the murine caspase 4 homolog caspase 11, and has a role in the immune system.^[1]

References

↑ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi: 10.1038/sj.cdd.4402038 . PMID 16977329.

External links

The MEROPS online database for peptidases and their inhibitors: C14.008

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[1] Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi: 10.1038/sj.cdd.4402038 . PMID 16977329.

[1]

v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Caspase 5

Contents

See also

References

External links