Caspase 4

CASP4
Identifiers
Aliases	CASP4 , ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Mih1, caspase 4
External IDs	OMIM: 602664; MGI: 107700; HomoloGene: 136493; GeneCards: CASP4; OMA:CASP4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q22.3 Start 104,942,866 bp [1] End 104,969,366 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A1|9 2.46 cM Start 5,308,828 bp [2] End 5,336,783 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood Achilles tendon upper lobe of left lung body of pancreas gallbladder right lung spleen epithelium of colon Top expressed in granulocyte jejunum ileum duodenum large intestine Paneth cell colon endothelial cell of lymphatic vessel uterus intestinal villus More reference expression data BioGPS n/a
Gene ontology Molecular function cysteine-type peptidase activity peptidase activity hydrolase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity CARD domain binding cysteine-type endopeptidase activity involved in apoptotic signaling pathway protein binding Cellular component NLRP3 inflammasome complex cytoplasm endoplasmic reticulum membrane membrane extracellular region AIM2 inflammasome complex IPAF inflammasome complex endoplasmic reticulum mitochondrion inflammasome complex cytosol plasma membrane protein-containing complex Biological process regulation of apoptotic process programmed cell death immune system process proteolysis intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of inflammatory response innate immune response inflammatory response cellular response to amyloid-beta apoptotic process execution phase of apoptosis positive regulation of tumor necrosis factor-mediated signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 837 12363 Ensembl ENSG00000196954 ENSMUSG00000033538 UniProt P49662 P70343 RefSeq (mRNA) NM_001225 NM_033306 NM_033307 NM_007609 RefSeq (protein) NP_001216 NP_150649 NP_031635 NP_001366247 NP_001366248 NP_001366249 NP_001366250 NP_001366251 NP_001366252 Location (UCSC) Chr 11: 104.94 – 104.97 Mb Chr 9: 5.31 – 5.34 Mb PubMed search [3] [4]
Wikidata
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Caspase 4 is an enzyme that in human is encoded by the CASP4 gene.

Caspase 4 proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system. ^[5]

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme. ^[6]

See also

• The Proteolysis Map
• Caspase

References

1. GRCh38: Ensembl release 89: ENSG00000196954 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033538 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi: 10.1038/sj.cdd.4402038 . PMID   16977329.
6. Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi: 10.1016/j.chembiol.2017.02.003 . PMC   5357154 . PMID   28238723.

External links

• The MEROPS online database for peptidases and their inhibitors: C14.007