CEMIP

CEMIP
Identifiers
Aliases	CEMIP , CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1
External IDs	OMIM: 608366; MGI: 2443629; HomoloGene: 10268; GeneCards: CEMIP; OMA:CEMIP - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q25.1 Start 80,779,343 bp [1] End 80,951,776 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 D3|7 48.35 cM Start 83,582,065 bp [2] End 83,735,710 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus trigeminal ganglion stromal cell of endometrium tibia pericardium cartilage tissue olfactory bulb lymph node right lobe of thyroid gland left lobe of thyroid gland Top expressed in calvaria vestibular sensory epithelium cranial dura mater stroma of bone marrow body of femur vestibular membrane of cochlear duct stria vascularis trigeminal ganglion gastrula lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin heavy chain binding ER retention sequence binding hydrolase activity, acting on glycosyl bonds protein binding hyaluronic acid binding hydrolase activity hyalurononglucosaminidase activity Cellular component cytoplasm membrane plasma membrane extracellular region endoplasmic reticulum clathrin-coated pit nucleus clathrin-coated vesicle membrane clathrin-coated endocytic vesicle Biological process hyaluronan biosynthetic process hyaluronan catabolic process positive regulation of cell migration positive regulation of protein kinase C activity positive regulation of release of sequestered calcium ion into cytosol hearing positive regulation of peptidyl-threonine phosphorylation metabolism positive regulation of protein targeting to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57214 80982 Ensembl ENSG00000103888 ENSMUSG00000052353 UniProt Q8WUJ3 Q8BI06 RefSeq (mRNA) NM_018689 NM_001293298 NM_001293304 NM_030728 RefSeq (protein) NP_001280227 NP_001280233 NP_061159 NP_109653 Location (UCSC) Chr 15: 80.78 – 80.95 Mb Chr 7: 83.58 – 83.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. ^[5] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. ^[6] Such function has also been validated in mice. ^[7]

CEMIP is associated with nonsyndromic deafness, ^[8] as well as a variety of cancers. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000103888 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052353 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KIAA1199 KIAA1199".
6. Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, Sakai S, Sugiyama Y, Enomoto H, Okada Y, Inoue S (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences. 110 (14): 5612–5617. Bibcode:2013PNAS..110.5612Y. doi: 10.1073/pnas.1215432110 . PMC   3619336 . PMID   23509262.
7. Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMC   3821019 . PMID   24251095.
8. Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet. 48 (11): 564–70. doi: 10.1007/s10038-003-0079-2 . PMID   14577002.
9. Zhang Y, Jia S, Jiang W (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports. 31 (4): 1503–1508. doi: 10.3892/or.2014.3038 . PMID   24573670.

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID   11247670.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Abe S, Katagiri T, Saito-Hisaminato A, et al. (2003). "Identification of CRYM as a Candidate Responsible for Nonsyndromic Deafness, through cDNA Microarray Analysis of Human Cochlear and Vestibular Tissues". Am. J. Hum. Genet. 72 (1): 73–82. doi:10.1086/345398. PMC   420014 . PMID   12471561.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Guo J, Cheng H, Zhao S, Yu L (2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Lett. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID   16406369. S2CID   1013478.