Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

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cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
Identifiers
EC no. 1.3.1.19
CAS no. 51923-03-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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Gene Ontology AmiGO / QuickGO
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In enzymology, cis-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.19) is an enzyme that catalyzes the chemical reaction

 
 
 
H+
Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
 
H+
 
 

The two substrates of this enzyme are cis-1,2-dihydrocatechol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are catechol, reduced NADH, and a proton. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase. Other names in common use include cis-benzene glycol dehydrogenase, cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine, and dinucleotide) oxidoreductase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, toluene and xylene degradation, naphthalene and anthracene degradation, and styrene degradation. [1]

References

  1. 1 2 Enzyme 1.3.1.19 at KEGG Pathway Database.
  2. Axcell BC, Geary PJ (1973). "The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase)". Biochem. J. 136 (4): 927–34. doi:10.1042/bj1360927. PMC   1166042 . PMID   4362337.
  3. Gibson DT, Koch JR, Kallio RE (1968). "Oxidative degradation of aromatic hydrocarbons by microorganisms. I Enzymatic formation of catechol from benzene". Biochemistry. 7 (7): 2653–62. doi:10.1021/bi00847a031. PMID   4298226.