Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase

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cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
Identifiers
EC no. 1.3.1.49
CAS no. 118390-61-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase (EC 1.3.1.49) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are (3S,4R)-3,4-dihydrophenanthrene-3,4-diol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are phenanthrene-3,4-diol, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase. This enzyme participates in naphthalene and anthracene degradation.

References

  1. Enzyme 1.3.1.49 at KEGG Pathway Database.
  2. Nagao K, Takizawa N, Kiyahara H (1988). "Purification and properties of cis-phenanthrene dihydrodiol dehydrogenase in Alcaligenes faecalis AFK2". Agric. Biol. Chem. 52 (10): 2621–2623. doi: 10.1271/bbb1961.52.2621 .