Costunolide synthase

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Costunolide synthase
Identifiers
EC no. 1.14.13.120
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Costunolide synthase (EC 1.14.13.120) is an enzyme with systematic name germacra-1(10),4,11(13)-trien-12-oate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). [1] This enzyme catalyses the following chemical reaction

germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2 (+)-costunolide + NADP+ + 2 H2O

Costunolide synthase is a heme-thiolate protein (P-450).

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References

  1. ↑ de Kraker JW, Franssen MC, Joerink M, de Groot A, Bouwmeester HJ (May 2002). "Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome p450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory". Plant Physiology. 129 (1): 257–68. doi:10.1104/pp.010957. PMC   155889 . PMID   12011356.


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