DAA-1097

DAA-1097

Identifiers
IUPAC name N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide
CAS Number	220551-79-1  Y
PubChem CID	9844410
ChemSpider	8020125
UNII	TE4VJ6U6XS
CompTox Dashboard (EPA)	DTXSID10431725
Chemical and physical data
Formula	C24H24ClNO3
Molar mass	409.91 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)Oc2ccccc2CN(C(=O)C)c1ccc(Cl)cc1Oc3ccccc3
InChI InChI=1S/C24H24ClNO3/c1-17(2)28-23-12-8-7-9-19(23)16-26(18(3)27)22-14-13-20(25)15-24(22)29-21-10-5-4-6-11-21/h4-15,17H,16H2,1-3H3 Key:CGUBOFYHGYNUDL-UHFFFAOYSA-N
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DAA-1097 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor.

It is also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at central benzodiazepine receptors.

It has anxiolytic effects in animal studies. ^{[1] [2] [3]}

References

1. Okuyama S, Chaki S, Yoshikawa R, Ogawa S, Suzuki Y, Okubo T, Nakazato A, Nagamine M, Tomisawa K (1999). "Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106". Life Sciences. 64 (16): 1455–64. doi:10.1016/S0024-3205(99)00079-X. PMID   10321725.
2. Okubo T, Yoshikawa R, Chaki S, Okuyama S, Nakazato A (January 2004). "Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands". Bioorganic & Medicinal Chemistry. 12 (2): 423–38. doi:10.1016/j.bmc.2003.10.050. PMID   14723961.
3. James ML, Selleri S, Kassiou M (2006). "Development of ligands for the peripheral benzodiazepine receptor" (PDF). Current Medicinal Chemistry. 13 (17): 1991–2001. doi:10.2174/092986706777584979. hdl: 2158/222808 . PMID   16842193.