DTDP-4-dehydrorhamnose reductase

dTDP-4-dehydrorhamnose reductase
Identifiers
EC no.	1.1.1.133
CAS no.	37250-64-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-mannose + NADP⁺${\displaystyle \rightleftharpoons }$ dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H⁺

Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP⁺, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP⁺ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KBZ, 1KC1, 1KC3, 1N2S, and 2GGS.

References

• Melo A, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose". J. Biol. Chem. 243 (7): 1475–8. doi: 10.1016/S0021-9258(18)93567-2 . PMID   4384782.