DTDP-4-dehydrorhamnose reductase

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dTDP-4-dehydrorhamnose reductase
Identifiers
EC no. 1.1.1.133
CAS no. 37250-64-9
Databases
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
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Gene Ontology AmiGO / QuickGO
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In enzymology, a dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-mannose + NADP+ dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+

Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KBZ, 1KC1, 1KC3, 1N2S, and 2GGS.

Related Research Articles

In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction

In enzymology, a dTDP-6-deoxy-L-talose 4-dehydrogenase (EC 1.1.1.134) is an enzyme that catalyzes the chemical reaction

In enzymology, a dTDP-galactose 6-dehydrogenase (EC 1.1.1.186) is an enzyme that catalyzes the chemical reaction

In enzymology, a fructose 5-dehydrogenase (NADP+) (EC 1.1.1.124) is an enzyme that catalyzes the chemical reaction

In enzymology, a GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) is an enzyme that catalyzes the chemical reaction

In enzymology, a GDP-4-dehydro-D-rhamnose reductase (EC 1.1.1.187) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">UDP-N-acetylmuramate dehydrogenase</span> Class of enzymes

In enzymology, an UDP-N-acetylmuramate dehydrogenase (EC 1.3.1.98) is an enzyme that catalyzes the chemical reaction

In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase (EC 1.1.1.126) is an enzyme that catalyzes the chemical reaction

CDP-4-dehydro-6-deoxyglucose reductase (EC 1.17.1.1) is an enzyme that catalyzes the chemical reaction

dTDP-4-dehydrorhamnose 3,5-epimerase Enzyme

In enzymology, a dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme that catalyzes the chemical reaction

The enzyme dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) catalyzes the chemical reaction

<span class="mw-page-title-main">GDP-mannose 4,6-dehydratase</span>

The enzyme GDP-mannose 4,6-dehydratase (EC 4.2.1.47) catalyzes the chemical reaction

In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">Thymidine diphosphate glucose</span> Chemical compound

Thymidine diphosphate glucose is a nucleotide-linked sugar consisting of deoxythymidine diphosphate linked to glucose. It is the starting compound for the syntheses of many deoxysugars.

DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) (EC 1.1.1.339, tll (gene name)) is an enzyme with systematic name dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase. This enzyme catalyses the following chemical reaction

References