Dehydrogluconate dehydrogenase

dehydrogluconate dehydrogenase
Identifiers
EC no.	1.1.99.4
CAS no.	9028-82-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, dehydrogluconate dehydrogenase (EC 1.1.99.4) is an enzyme that catalyzes the chemical reaction

2-dehydro-D-gluconic acid

+ electron acceptor

 

 

 

 

 

 

 

2,5-didehydro-D-gluconic acid

+ reduced acceptor

 

The two substrates of this enzyme are 2-dehydro-D-gluconic acid and an electron acceptor. Its products are 2,5-didehydro-D-gluconic acid and the corresponding reduced acceptor. ^{[1] [2] [3]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is 2-dehydro-D-gluconate:acceptor 2-oxidoreductase. Other names in common use include ketogluconate dehydrogenase, alpha-ketogluconate dehydrogenase, 2-keto-D-gluconate dehydrogenase, and 2-oxogluconate dehydrogenase. It has 2 cofactors: FAD, and a flavoprotein.

References

1. Enzyme 1.1.99.4 at KEGG Pathway Database.
2. Datta AG, Katznelson H (1956). "The oxidation of 2-ketogluconate by a partially purified enzyme from Acetobactor melanogenum". Arch. Biochem. Biophys. 65 (2): 576–8. doi:10.1016/0003-9861(56)90218-1. PMID   13395514.
3. Shinagawa E; Ameyama M (1982). "2-Keto-d-gluconate dehydrogenase from Gluconobacter melanogenus, membrane-bound". Carbohydrate Metabolism - Part D. Methods Enzymol. Vol. 89. pp. 194–198. doi:10.1016/S0076-6879(82)89034-4. ISBN   978-0-12-181989-7.