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Names | |
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Preferred IUPAC name 3-[3-(4′-Bromo[1,1′-biphenyl]-4-yl)naphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
ECHA InfoCard | 100.118.383 |
KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C31H23BrO2S | |
Molar mass | 539.49 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Difethialone is an vitamin K antagonist anticoagulant used as a rodenticide. [1] It is considered a second generation agent. [2]
It belongs to the 4-thiochromenone or benzothiopyranone class of rodenticides, which differs from 4-hydroxycoumarins by the substitution of an oxygen atom with sulfur. It is especially similar to brodifacoum. It shares the same mechanism of inhibiting Vkorc1. It is effective for warfarin-resistant and warfarin-susceptible rodents. [1] Its high potency makes resistance harder to evolve, though a few populations of rodents have nevertheless managed to do so. [3]
In May 2008, the EPA added restrictions on the sale of difethialone in consumer-use rodenticide products and also for exterior use by commercial applicators. [4] [5]