Pindone

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Pindone
Pindone Structural Formula V.1.svg
Names
Preferred IUPAC name
2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione
Other names
2-Pivaloyl-1,3-indandione
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.001.330 OOjs UI icon edit-ltr-progressive.svg
KEGG
PubChem CID
UNII
  • InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 Yes check.svgY
    Key: RZKYEQDPDZUERB-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3
    Key: RZKYEQDPDZUERB-UHFFFAOYAX
  • O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
C14H14O3
Molar mass 230.26 g/mol
AppearanceBright-yellow powder [1]
Odor almost none
Density 1.06 g/mL
Melting point 110 °C (230 °F; 383 K)
0.002% (25°C) [1]
Hazards
Lethal dose or concentration (LD, LC):
280 mg/kg (rat, oral)
75 mg/kg (dog, oral)
150 mg/kg (rabbit, oral) [2]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 0.1 mg/m3 [1]
REL (Recommended)
TWA 0.1 mg/m3 [1]
IDLH (Immediate danger)
100 mg/m3 [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pindone is an anticoagulant drug [3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

See also

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References

  1. 1 2 3 4 5 NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
  2. "Pindone". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID   15694595.