Pindone

Last updated
Pindone
Pindone Structural Formula V.1.svg
Names
IUPAC name
2-(2,2-Dimethyl-1-oxopropyl)indane-1,3-dione
Other names
2-Pivaloyl-1,3-indandione
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.001.330
KEGG
PubChem CID
Properties
C14H14O3
Molar mass 230.26 g/mol
AppearanceBright-yellow powder [1]
Odor almost none
Density 1.06 g/mL
Melting point 110 °C (230 °F; 383 K)
0.002% (25°C) [1]
Hazards
Lethal dose or concentration (LD, LC):
280 mg/kg (rat, oral)
75 mg/kg (dog, oral)
150 mg/kg (rabbit, oral) [2]
US health exposure limits (NIOSH):
PEL (Permissible)
TWA 0.1 mg/m3 [1]
REL (Recommended)
TWA 0.1 mg/m3 [1]
IDLH (Immediate danger)
100 mg/m3 [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pindone is an anticoagulant drug [3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, and dialysis equipment. They can also be used as rodenticides.

Drug Substance having an effect on the body

A drug is any substance that causes a change in an organism's physiology or psychology when consumed.

Rodenticide Substances used to destroy or inhibit the action of rats, mice, or other rodents

Rodenticides, colloquially rat poison, are typically non-specific pest control chemicals made and sold for the purpose of killing rodents.

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

Warfarin medication that is used as an anticoagulant

Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant. It is commonly used to treat blood clots such as deep vein thrombosis and pulmonary embolism and to prevent stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves. Less commonly it is used following ST-segment elevation myocardial infarction (STEMI) and orthopedic surgery. It is generally taken by mouth but may also be used by injection into a vein.

Vitamin K vitamin

Vitamin K is a group of structurally similar, fat-soluble vitamins found in foods and in dietary supplements. The human body requires vitamin K for complete synthesis of certain proteins that are needed for blood coagulation or for controlling binding of calcium in bones and other tissues. The vitamin K-related modification of the proteins allows them to bind calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Preliminary clinical research indicates that deficiency of vitamin K may weaken bones, potentially leading to osteoporosis, and may promote calcification of arteries and other soft tissues.

See also

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References

  1. 1 2 3 4 5 NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
  2. "Pindone". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID   15694595.