Ent-kaurenoic acid oxidase

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Ent-kaurenoic acid oxidase
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EC no. 1.14.13.79
CAS no. 337507-95-6
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Ent-kaurenoic acid oxidase (EC 1.14.13.79) is an enzyme with systematic name ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating). [1] This enzyme catalyses the following chemical reaction

ent-kaur-16-en-19-oate + 3 NADPH + 3 H+ + 3 O2 gibberellin A12 + 3 NADP+ + 4 H2O (overall reaction)
(1a) ent-kaur-16-en-19-oate + NADPH + H+ + O2 ent-7alpha-hydroxykaur-16-en-19-oate + NADP+ + H2O
(1b) ent-7alpha-hydroxykaur-16-en-19-oate + NADPH + H+ + O2 gibberellin A12 aldehyde + NADP+ + 2 H2O
(1c) gibberellin A12 aldehyde + NADPH + H+ + O2 gibberellin A12 + NADP+ + H2O

Ent-kaurenoic acid oxidase requires cytochrome P450.

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References

  1. ↑ Helliwell CA, Chandler PM, Poole A, Dennis ES, Peacock WJ (February 2001). "The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 2065–70. doi: 10.1073/pnas.041588998 . PMC   29382 . PMID   11172076.


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