Galactitol 2-dehydrogenase

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galactitol 2-dehydrogenase
Identifiers
EC no. 1.1.1.16
CAS no. 9028-23-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a galactitol 2-dehydrogenase (EC 1.1.1.16) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Biochem reaction arrow reversible NYYN horiz med.svg
 
H+
 
+ NADH
 

The two substrates of this enzyme are galactitol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are D-tagatose, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is galactitol:NAD+ 2-oxidoreductase. This enzyme is also called dulcitol dehydrogenase. This enzyme participates in galactose metabolism.

References

  1. ↑ Enzyme 1.1.1.16 at KEGG Pathway Database.
  2. ↑ Shaw DR (November 1956). "Polyol dehydrogenases. 3. Galactitol dehydrogenase and D-iditol dehydrogenase". The Biochemical Journal. 64 (3): 394–405. doi:10.1042/bj0640394. PMC   1199749 . PMID   13373783.