Galactonolactone dehydrogenase

L-galactonolactone dehydrogenase
Identifiers
EC no.	1.3.2.3
CAS no.	2603847
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

L-galactonolactone dehydrogenase (EC 1.3.2.3, galactonolactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase, GLDHase, GLDase) is an enzyme with systematic name L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase. ^{[1] [2] [3] [4]} This enzyme catalyses two chemical reactions

L-galactono-1,4-lactone

+ 2 ferricytochrome c

 

 

 

2 H⁺

 

2 H⁺

 

vitamin C

2 ferrocytochrome c

 

vitamin C

+ 2 ferricytochrome c

 

 

 

2 H⁺

 

2 H⁺

 

dehydroascorbic acid

2 ferrocytochrome c

 

The first stage is the final step in the biosynthesis of vitamin C in plants and other photosynthetic eukaryotes. ^{[5] [6] [7]}

References

1. Mapson, L.W.; Breslow, E. (1957). "Properties of partially purified L-galactono-γ-lactone dehydrogenase". Biochem. J. 65: 29.
2. Mapson LW, Isherwood FA, Chen YT (January 1954). "Biological synthesis of L-ascorbic acid: the conversion of L-galactono-gamma-lactone into L-ascorbic acid by plant mitochondria". The Biochemical Journal. 56 (1): 21–8. doi:10.1042/bj0560021. PMC   1269564 . PMID   13126087.
3. Oba K, Ishikawa S, Nishikawa M, Mizuno H, Yamamoto T (January 1995). "Purification and properties of L-galactono-gamma-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots". Journal of Biochemistry. 117 (1): 120–4. doi: 10.1093/oxfordjournals.jbchem.a124697 . PMID   7775377.
4. Ostergaard J, Persiau G, Davey MW, Bauw G, Van Montagu M (November 1997). "Isolation of a cDNA coding for L-galactono-gamma-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast". The Journal of Biological Chemistry. 272 (48): 30009–16. doi: 10.1074/jbc.272.48.30009 . PMID   9374475.
5. Enzyme 1.3.2.3 at KEGG Pathway Database.
6. Isherwood FA, Chen YT, Mapson LW (January 1954). "Synthesis of L-ascorbic acid in plants and animals". The Biochemical Journal. 56 (1): 1–15. doi:10.1042/bj0560001. PMC   1269562 . PMID   13126085.
7. Wheeler G, Ishikawa T, Pornsaksit V, Smirnoff N (March 2015). "Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes". eLife. 4. doi: 10.7554/eLife.06369 . PMC   4396506 . PMID   25768426.

External links

• L-galactonolactone+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)