Germacrene A hydroxylase

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Germacrene A hydroxylase
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EC no. 1.14.13.123
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Germacrene A hydroxylase (EC 1.14.13.123) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating). [1] [2] This enzyme catalyses the following chemical reaction

(+)-germacrene A + NADPH + H+ + O2 germacra-1(10),4,11(13)-trien-12-ol + NADP+ + H2O

Germacrene A hydroxylase is a heme-thiolate protein (P-450).

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References

  1. ↑ de Kraker JW, Franssen MC, Dalm MC, de Groot A, Bouwmeester HJ (April 2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis". Plant Physiology. 125 (4): 1930–40. doi:10.1104/pp.125.4.1930. PMC   88848 . PMID   11299372.
  2. ↑ Nguyen DT, Göpfert JC, Ikezawa N, Macnevin G, Kathiresan M, Conrad J, Spring O, Ro DK (May 2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae". The Journal of Biological Chemistry. 285 (22): 16588–98. doi: 10.1074/jbc.M110.111757 . PMC   2878029 . PMID   20351109.


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