Gluconate 2-dehydrogenase (acceptor)

Last updated
Gluconate 2-dehydrogenase (acceptor)
Identifiers
EC no. 1.1.99.3
CAS no. 9028-81-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a gluconate 2-dehydrogenase (acceptor) (EC 1.1.99.3) is an enzyme that catalyzes the chemical reaction

 
 
 
Gluconate 2-dehydrogenase (acceptor)
 
 
 
+ reduced acceptor
 

The two substrates of this enzyme are D-gluconic acid and an electron acceptor. Its products are 2-dehydro-D-gluconic acid and the corresponding reduced acceptor. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-gluconate:acceptor 2-oxidoreductase. Other names in common use include gluconate oxidase, gluconate dehydrogenase, gluconic dehydrogenase, D-gluconate dehydrogenase, gluconic acid dehydrogenase, 2-ketogluconate reductase, D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding, and D-gluconate:(acceptor) 2-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.

References

  1. Enzyme 1.1.99.3 at KEGG Pathway Database.
  2. Matsushita K, Shinagawa E, Ameyama M (1982). "D-Gluconate dehydrogenase from bacteria, 2-keto-d-gluconate-yielding, membrane-bound". Carbohydrate Metabolism - Part D. Methods in Enzymology. Vol. 89. pp. 187–93. doi:10.1016/s0076-6879(82)89033-2. ISBN   978-0-12-181989-7. PMID   6815420.
  3. Ramakrishnan T; Campbell JJR (1955). "Gluconic dehydrogenase of Pseudomonas aeruginosa". Biochim. Biophys. Acta. 17 (1): 122–127. doi:10.1016/0006-3002(55)90326-7. PMID   13239635.