Glucose-fructose oxidoreductase

glucose-fructose oxidoreductase
Identifiers
EC no.	1.1.99.28
CAS no.	94949-35-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, glucose-fructose oxidoreductase (EC 1.1.99.28) is an enzyme that catalyzes the chemical reaction

D-glucose

+

 

D-fructose

 

 

 

 

 

 

glucono-δ-lactone

+

 

D-sorbitol

The two substrates of this enzyme are D-glucose and D-fructose (shown in its open-chain keto form). Its products are glucono-δ-lactone and sorbitol. ^{[1] [2] [3] [4]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-glucose:D-fructose oxidoreductase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1H6A, 1H6B, 1H6C, 1H6D, 1OFG, 1RYD, and 1RYE.

References

1. Enzyme 1.1.99.28 at KEGG Pathway Database.
2. Zachariou M; Scopes RK (1986). "Glucose-fructose oxidoreductase: a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production". J. Bacteriol. 167 (3): 863–869. doi:10.1128/JB.167.3.863-869.1986. PMC   215953 . PMID   3745122.
3. Hardman MJ, Scopes RK (1988). "The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis". Eur. J. Biochem. 173 (1): 203–9. doi: 10.1111/j.1432-1033.1988.tb13985.x . PMID   3356190.
4. Kanagasundaram V, Scopes RK (1992). "Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis". J. Bacteriol. 174 (5): 1439–47. doi:10.1128/jb.174.5.1439-1447.1992. PMC   206538 . PMID   1537789.