Hyalobarrier

Last updated October 03, 2025

Hyalobarrier is a substance to keep tissue apart post surgery and therefore prevent adhesions. It contains autocross-linked hyaluronan. Highly viscous due to condensation. Hyaluronan is present in cartilage and skin hence there is a natural metabolic pathway for it. This gel is used to separate organs and tissue after surgery.

Scientific documentation so far covers the gynaecology speciality. IE Laparoscopic surgery, hysteroscopy/hysteroscopic surgery but also open surgery.

According to data in a Cochrane collaboration review barrier agents may be a little more effective in preventing adhesions than no intervention. The Cochrane report also states that the incidence of postsurgical adhesions is as high as 50 to 100%.^[1] In a recent review by C Sutton (University of Surrey, Guilford UK), it is stated that Hyalobarrier is the only anti adhesive substance that has published data for intrauterine use.^[2]

Additional information

References

Mais V, Bracco GL, Litta P, Gargiulo T, Melis GB (May 2006). "Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study". Hum. Reprod. 21 (5): 1248–54. doi: 10.1093/humrep/dei488 . PMID 16439505.

↑ Ahmad, Gaity; Kim, Kyungmin; Thompson, Matthew; Agarwal, Priya; O'Flynn, Helena; Hindocha, Akshay; Watson, Andrew (March 22, 2020). "Barrier agents for adhesion prevention after gynaecological surgery". The Cochrane Database of Systematic Reviews. 3 (3) CD000475. doi:10.1002/14651858.CD000475.pub4. ISSN 1469-493X. PMC 7085418 . PMID 32199406.
↑ Sutton C (2009). "Adhesions following surgery: pathogenesis and current experience with adhesion barriers". Surg Technol Int. 18: 144–56. PMID 19579202.

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[1] Ahmad, Gaity; Kim, Kyungmin; Thompson, Matthew; Agarwal, Priya; O'Flynn, Helena; Hindocha, Akshay; Watson, Andrew (March 22, 2020). "Barrier agents for adhesion prevention after gynaecological surgery". The Cochrane Database of Systematic Reviews. 3 (3) CD000475. doi:10.1002/14651858.CD000475.pub4. ISSN 1469-493X. PMC 7085418 . PMID 32199406.

[2] Sutton C (2009). "Adhesions following surgery: pathogenesis and current experience with adhesion barriers". Surg Technol Int. 18: 144–56. PMID 19579202.

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