Infusion pump

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A type of infusion pump, manufactured by Fresenius. Infusionspumpe.JPG
A type of infusion pump, manufactured by Fresenius.

An infusion pump infuses fluids, medication or nutrients into a patient's circulatory system. It is generally used intravenously, although subcutaneous, arterial and epidural infusions are occasionally used.

Contents

Infusion pumps can administer fluids in ways that would be impractically expensive or unreliable if performed manually by nursing staff. For example, they can administer as little as 0.1 mL per hour injections (too small for a drip), injections every minute, injections with repeated boluses requested by the patient, up to maximum number per hour (e.g. in patient-controlled analgesia), or fluids whose volumes vary by the time of day.

Because they can also produce quite high but controlled pressures, they can inject controlled amounts of fluids subcutaneously (beneath the skin), or epidurally (just within the surface of the central nervous system – a very popular local spinal anesthesia for childbirth).

Types of infusion

The user interface of pumps usually requests details on the type of infusion from the technician or nurse that sets them up:

To get the entire dose of antibiotics into the patient, the "volume to be infused" or VTBI must be programmed for at least 30 CCs more than is in the medication bag; failure to do so can potentially result in up to half of the antibiotic being left in the IV tubing.

Some pumps offer modes in which the amounts can be scaled or controlled based on the time of day. This allows for circadian cycles which may be required for certain types of medication.

Types of pump

A Baxter International Colleague CX infusion pump Baxter Colleague CX infusion pump.JPG
A Baxter International Colleague CX infusion pump
Patient in an intensive care unit in a German hospital in 2015, with two staples of four to five stationary infusion pumps each, on top right behind him (resp. behind the visitor). Patient lying in hospital bed in intensive care unit in Germany in 2015.jpg
Patient in an intensive care unit in a German hospital in 2015, with two staples of four to five stationary infusion pumps each, on top right behind him (resp. behind the visitor).

There are two basic classes of pumps. Large volume pumps can pump fluid replacement such as saline solution, medications such as antibiotics or nutrient solutions large enough to feed a patient. Small-volume pumps infuse hormones, such as insulin, or other medicines, such as opiates.

Within these classes, some pumps are designed to be portable, others are designed to be used in a hospital, and there are special systems for charity and battlefield use.

Large-volume pumps usually use some form of peristaltic pump. Classically, they use computer-controlled rollers compressing a silicone-rubber tube through which the medicine flows. Another common form is a set of fingers that press on the tube in sequence.

Small-volume pumps usually use a computer-controlled motor turning a screw that pushes the plunger on a syringe.

The classic medical improvisation for an infusion pump is to place a blood pressure cuff around a bag of fluid. The battlefield equivalent is to place the bag under the patient. The pressure on the bag sets the infusion pressure. The pressure can actually be read-out at the cuff's indicator. The problem is that the flow varies dramatically with the cuff's pressure (or patient's weight), and the needed pressure varies with the administration route, potentially causing risk when attempted by an individual not trained in this method.

Places that must provide the least-expensive care often use pressurized infusion systems. One common system has a purpose-designed plastic "pressure bottle" pressurized with a large disposable plastic syringe. A combined flow restrictor, air filter and drip chamber helps a nurse set the flow. The parts are reusable, mass-produced sterile plastic, and can be produced by the same machines that make plastic soft-drink bottles and caps. A pressure bottle, restrictor and chamber requires more nursing attention than electronically controlled pumps. In the areas where these are used, nurses are often volunteers, or very inexpensive.

The restrictor and high pressure helps control the flow better than the improvised schemes because the high pressure through the small restrictor orifice reduces the variation of flow caused by patients' blood pressures.

An air filter is an essential safety device in a pressure infusor, to keep air out of the patients' veins. Small bubbles could cause harm in arteries, but in the veins they pass through the heart and leave in the patients' lungs. The air filter is just a membrane that passes gas but not fluid or pathogens. When a large air bubble reaches it, it bleeds off.

Some of the smallest infusion pumps use osmotic power. Basically, a bag of salt solution absorbs water through a membrane, swelling its volume. The bag presses medicine out. The rate is precisely controlled by the salt concentrations and pump volume. Osmotic pumps are usually recharged with a syringe.

Spring-powered clockwork infusion pumps have been developed, and are sometimes still used in veterinary work and for ambulatory small-volume pumps. They generally have one spring to power the infusion, and another for the alarm bell when the infusion completes.

Battlefields often have a need to perfuse large amounts of fluid quickly, with dramatically changing blood pressures and patient condition. Specialized infusion pumps have been designed for this purpose, although they have not been deployed.

Many infusion pumps are controlled by a small embedded system. They are carefully designed so that no single cause of failure can harm the patient. For example, most have batteries in case the wall-socket power fails. Additional hazards are uncontrolled flow causing an overdose, uncontrolled lack of flow, causing an underdose, reverse flow, which can siphon blood from a patient, and air in the line, which can cause an air embolism.

Safety features available on some pumps

The range of safety features varies widely with the age and make of the pump. A state of the art pump in 2003 might have had the following safety features:

By 2019 intravenous smart pumps were being introduced. They could include wireless connectivity, drug libraries, profiles of care areas, and soft and hard limits. [1]

Safety issues

Infusion pumps have been a source of multiple patient safety concerns, and problems with such pumps have been linked to more than 56,000 adverse event reports from 2005 to 2009, including at least 500 deaths. [2] As a result, the U.S. Food and Drug Administration (FDA) has launched a comprehensive initiative to improve their safety, called the Infusion Pump Improvement Initiative. [3] The initiative proposed stricter regulation of infusion pumps. It cited software defects, user interface issues, and mechanical or electrical failures as the main causes of adverse events.

See also

Related Research Articles

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Patient-controlled analgesia (PCA) is any method of allowing a person in pain to administer their own pain relief. The infusion is programmable by the prescriber. If it is programmed and functioning as intended, the machine is unlikely to deliver an overdose of medication. Providers must always observe the first administration of any PCA medication which has not already been administered by the provider to respond to allergic reactions.

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ICU Medical, Inc. is a San Clemente, California-based company with global operations. ICU Medical products are designed to prevent bloodstream infections and protect healthcare workers from exposure to infectious diseases or hazardous drugs. ICU Medical product line includes intravenous therapy (IV) products, pumps, needle-free vascular access devices, custom infusion sets, closed system hazardous drug handling devices and systems, sensor catheters, needle-free closed blood sampling systems, and hemodynamic monitoring systems.

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References

  1. Davis, S.; Blanchard, C.; Lewis, J. (26 October 2018). "Implementing Smart Pumps to Enhance Patient Safety". Hospital Pharmacy. 54 (4): 217–219. doi:10.1177/0018578718809252. PMC   6628554 . PMID   31320768.
  2. Pharmacy Practice News, May 2010
  3. "White Paper: Infusion Pump Improvement Initiative". FDA. 14 January 2020.