Effervescent tablet

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An effervescent tablet in a glass of water Brausetablette.JPG
An effervescent tablet in a glass of water
An effervescent tablet with cleaning agent for dentures dissolves in a glass of water

Effervescent or carbon tablets are tablets which are designed to dissolve in water and release carbon dioxide. The carbon dioxide is generated by a reaction of a compound containing bicarbonate, such as sodium bicarbonate or magnesium bicarbonate, with an acid such as citric acid or tartaric acid. Both compounds are present in the tablet in powder form and start reacting as soon as they dissolve in water. [1] [2] [3] [4]

Contents

Effervescent tablets are made by compression of ingredients in the form of powders into a dense mass, which is packaged in blister pack, or with a hermetically sealed package with incorporated desiccant in the cap. To use them, they are dropped into water to make a solution. The powdered ingredients are also packaged and sold as effervescent powders or may be granulated and sold as effervescent granules. Generally powdered ingredients are first granularized before being made into tablets. [5] [6]

Effervescent medicinal beverages date back to the late 1800s and originally arose to mask the taste of bitter waters taken as curatives, during the water cure craze of that era. [7]

History

In the 17th and 18th centuries, scientists began uncovering the chemical make-up and physiological benefits of various salts such as Glauber's salt and Epsom salts. [7] These salts were found in mineral springs, which, since the Roman Empire, [8] [9] [10] [10] had been used as health spas, where people would go to bathe in, and drink, mineral-rich waters for their health. These developments led to attempts to replicate the salt mixtures found in these naturally occurring mineral waters using off-the-shelf ingredients. [7] Mixing these kinds of salts — especially carbonates and tartrates — with flavorings like lemon into an effervescent compound with citric or tartaric acid proved especially popular and set off a craze for the new "fruit salts". Effervescent tablets have been used as products of the pharmaceutical and dietary industries for over two centuries. [7]

Use

In by-mouth medicine

Vitamins may be sold as effervescent tablets.

There are several categories of active ingredients that may be best administered in the form of effervescent preparations:

  1. Those that are difficult to digest or disruptive to the stomach or esophagus [11]
  2. Those that are pH–sensitive, such as amino acids and antibiotics.
  3. Those requiring a large dose.
  4. Those that are susceptible to light, oxygen, or moisture.
  5. It is used as a gastrointestinal agent.

Effervescent preparations may enhance absorption and speed up onset of action by increasing gastric pH, therefore hastening the emptying of medication into the small intestine. [12] The carbon dioxide bubbles may also help intestinal absorption by opening up paracellular transport. [13] Extreme bioavailability differences of up to 4-fold have been reported comparing effervescent tablets with ordinary tablets, highlighting the need for extra bioequivalence studies when switching dosage forms. [14]

It is dangerous to swallow an effervescent tablet directly, as the tablet can get stuck in the subglottis and fizzle there. A potentially fatal edema may occur from the irritation. [15] In addition, conventional effervescent tablets contain a significant amount of sodium and are associated with increased odds of adverse cardiovascular events according to a 2013 study. Low or no-sodium formulations exist. [16]

Other

"Cleaning tablets" are formulations carrying detergents for cleaning. They may be used in laundry, in cleaning of specific machines or containers, in cleaning of dentures and contact lenses, [17] etc.

Some tablets used for dyeing eggs for Easter are effervescent.

There also exist effervescent tablets for making carbonated drinks or soda water.

Capsules

Effervescent tablets mostly come in capsules constructed for these tablets. They may contain an anti-bacterial coating and are water resistant. The cap contains a little spring-like spiral, which helps keeping the tablets in place during transportation and prevents them from breaking. The cap also contains little balls made out of silica gel. [18] They sit after a little piece of cardboard and make sure no moisture comes into contact with the tablets.

See also

Related Research Articles

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<span class="mw-page-title-main">Carbonate</span> Salt or ester of carbonic acid

A carbonate is a salt of carbonic acid, H2CO3, characterized by the presence of the carbonate ion, a polyatomic ion with the formula CO2−3. The word "carbonate" may also refer to a carbonate ester, an organic compound containing the carbonate groupO=C(−O−)2.

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<span class="mw-page-title-main">Tablet (pharmacy)</span> Drug delivery form in which the ingredients are solidified for later consumption

A tablet is a pharmaceutical oral dosage form or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medication with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid dose. The main advantages of tablets are that they ensure a consistent dose of medicine that is easy to consume.

<span class="mw-page-title-main">Sodium bicarbonate</span> Chemical compound

Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO3. It is a salt composed of a sodium cation (Na+) and a bicarbonate anion (HCO3). Sodium bicarbonate is a white solid that is crystalline but often appears as a fine powder. It has a slightly salty, alkaline taste resembling that of washing soda (sodium carbonate). The natural mineral form is nahcolite. It is a component of the mineral natron and is found dissolved in many mineral springs.

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Sodium carbonate is the inorganic compound with the formula Na2CO3 and its various hydrates. All forms are white, odourless, water-soluble salts that yield alkaline solutions in water. Historically, it was extracted from the ashes of plants grown in sodium-rich soils, and because the ashes of these sodium-rich plants were noticeably different from ashes of wood, sodium carbonate became known as "soda ash". It is produced in large quantities from sodium chloride and limestone by the Solvay process, as well as by carbonating sodium hydroxide which is made using the Chlor-alkali process.

<span class="mw-page-title-main">Baking powder</span> Dry chemical leavening agent

Baking powder is a dry chemical leavening agent, a mixture of a carbonate or bicarbonate and a weak acid. The base and acid are prevented from reacting prematurely by the inclusion of a buffer such as cornstarch. Baking powder is used to increase the volume and lighten the texture of baked goods. It works by releasing carbon dioxide gas into a batter or dough through an acid–base reaction, causing bubbles in the wet mixture to expand and thus leavening the mixture. The first single-acting baking powder was developed by food manufacturer Alfred Bird in England in 1843. The first double-acting baking powder, which releases some carbon dioxide when dampened and later releases more of the gas when heated by baking, was developed by Eben Norton Horsford in the U.S. in the 1860s.

<span class="mw-page-title-main">Potassium bicarbonate</span> Chemical compound

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<span class="mw-page-title-main">Carbonated water</span> Water containing dissolved carbon dioxide gas

Carbonated water is water containing dissolved carbon dioxide gas, either artificially injected under pressure or occurring due to natural geological processes. Carbonation causes small bubbles to form, giving the water an effervescent quality. Common forms include sparkling natural mineral water, club soda, and commercially produced sparkling water.

<span class="mw-page-title-main">Magnesium carbonate</span> Chemical compound

Magnesium carbonate, MgCO3, is an inorganic salt that is a colourless or white solid. Several hydrated and basic forms of magnesium carbonate also exist as minerals.

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Ammonium carbonate is a salt with the chemical formula (NH4)2CO3. Since it readily degrades to gaseous ammonia and carbon dioxide upon heating, it is used as a leavening agent and also as smelling salt. It is also known as baker's ammonia and is a predecessor to the more modern leavening agents baking soda and baking powder. It is a component of what was formerly known as sal volatile and salt of hartshorn, and produces a pungent smell when baked. It comes in the form of a white powder or block, with a molar mass of 96.09 g/mol and a density of 1.50 g/cm3. It is a strong electrolyte.

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References

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