Mannitol 2-dehydrogenase

mannitol 2-dehydrogenase
Identifiers
EC no.	1.1.1.67
CAS no.	9001-65-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a mannitol 2-dehydrogenase (EC 1.1.1.67) is an enzyme that catalyzes the chemical reaction

Mannitol

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

Fructose

+ NADH

 

The two substrates of this enzyme are D-mannitol and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are D-fructose (shown in its keto form), reduced NADH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannitol:NAD⁺ 2-oxidoreductase. Other names in common use include D-mannitol dehydrogenase, and mannitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LJ8 and 1M2W.

References

1. Enzyme 1.1.1.67 at KEGG Pathway Database.
2. Martinez G, Barker HA, Horecker BL (1963). "A specific mannitol dehydrogenase from Lactobacillus brevis". J. Biol. Chem. 238 (5): 1598–1603. doi: 10.1016/S0021-9258(18)81106-1 .