Methanol dehydrogenase (nicotinoprotein)

Methanol dehydrogenase (nicotinoprotein)
Identifiers
EC no.	1.1.99.37
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Methanol dehydrogenase (nicotinoprotein) (EC 1.1.99.37, NDMA-dependent methanol dehydrogenase, nicotinoprotein methanol dehydrogenase, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with systematic name methanol:acceptor oxidoreductase. ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

methanol + acceptor ${\displaystyle \rightleftharpoons }$ formaldehyde + reduced acceptor

This enzyme contains Zn²⁺ and Mg²⁺.

References

1. Vonck J, Arfman N, De Vries GE, Van Beeumen J, Van Bruggen EF, Dijkhuizen L (February 1991). "Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1". The Journal of Biological Chemistry. 266 (6): 3949–54. doi: 10.1016/S0021-9258(19)67885-3 . PMID   1995642.
2. Van Ophem PW, Van Beeumen J, Duine JA (March 1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". European Journal of Biochemistry. 212 (3): 819–26. doi: 10.1111/j.1432-1033.1993.tb17723.x . PMID   8385013.
3. Bystrykh LV, Vonck J, van Bruggen EF, van Beeumen J, Samyn B, Govorukhina NI, Arfman N, Duine JA, Dijkhuizen L (March 1993). "Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19". Journal of Bacteriology. 175 (6): 1814–22. doi:10.1128/jb.175.6.1814-1822.1993. PMC   203978 . PMID   8449887.
4. Hektor HJ, Kloosterman H, Dijkhuizen L (December 2002). "Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus" (PDF). The Journal of Biological Chemistry. 277 (49): 46966–73. doi: 10.1074/jbc.M207547200 . PMID   12351635.
5. Park H, Lee H, Ro YT, Kim YM (February 2010). "Identification and functional characterization of a gene for the methanol : N,N'-dimethyl-4-nitrosoaniline oxidoreductase from Mycobacterium sp. strain JC1 (DSM 3803)". Microbiology. 156 (Pt 2): 463–71. doi: 10.1099/mic.0.034124-0 . PMID   19875438.

External links

• Methanol+dehydrogenase+(nicotinoprotein) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)