Myristoyl-CoA 11-(E) desaturase

myristoyl-CoA 11-(E) desaturase
Identifiers
EC no.	1.14.99.31
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a myristoyl-CoA 11-(E) desaturase (EC 1.14.99.31) is an enzyme that catalyzes the chemical reaction

myristoyl-CoA + NAD(P)H + H⁺ + O₂${\displaystyle \rightleftharpoons }$ (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H₂O

The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H⁺, and O₂, whereas its 4 products are (E)-11-tetradecenoyl-CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating].

References

• Navaro I, Font I, Fabrias G, Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119 (46): 11335–11336. doi:10.1021/ja972577v.