Pentalenolactone F synthase

Pentalenolactone F synthase
Identifiers
EC no.	1.14.11.36
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pentalenolactone F synthase (EC 1.14.11.36, PEND (gene), PNTD (gene), PTLD (gene)) is an enzyme with systematic name pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase. ^[1] This enzyme catalyses the following chemical reaction

pentalenolactone D + 2 2-oxoglutarate + 2 O₂${\displaystyle \rightleftharpoons }$ pentalenolactone F + 2 succinate + 2 CO₂ + H₂O (overall reaction)

(1a) pentalenolactone D + 2-oxoglutarate + O₂${\displaystyle \rightleftharpoons }$ pentalenolactone E + succinate + CO₂ + H₂O

(1b) pentalenolactone E + 2-oxoglutarate + O₂${\displaystyle \rightleftharpoons }$ pentalenolactone F + succinate + CO₂

Pentalenolactone F synthase contains Fe(II), and ascorbate is needed for its action.

References

1. Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE (March 2011). "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone". Biochemistry. 50 (10): 1739–54. doi:10.1021/bi1019786. PMC   3051010 . PMID   21250661.

External links

• Pentalenolactone+F+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)