Phloroglucinol reductase

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phloroglucinol reductase
Identifiers
EC no. 1.3.1.57
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, phloroglucinol reductase (EC 1.3.1.57) is an enzyme that catalyzes the chemical reaction

Dihydrophloroglucinol.svg
(1)
 
 
 
H+
Phloroglucinol reductase
 
H+
 
Phloroglucin.svg
(2)
 

The two substrates of this enzyme are dihydrophloroglucinol (1) and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are phloroglucinol (2), reduced NADPH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dihydrophloroglucinol:NADP+ oxidoreductase. This enzyme participates in benzoate degradation via CoA ligation.

References

  1. Enzyme 1.3.1.57 at KEGG Pathway Database.
  2. Haddock JD, Ferry JG (1989). "Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41". J. Biol. Chem. 264 (8): 4423–7. doi: 10.1016/S0021-9258(18)83759-0 . PMID   2925649.